3-methoxy-2-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-5,5-dimethylcyclohex-2-en-1-one | 1308887-12-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-methoxy-2-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-5,5-dimethylcyclohex-2-en-1-one
• 英文别名: 3-Methoxy-2-[(e)-3-(4-methoxyphenyl)prop-2-enoyl]-5,5-dimethylcyclohex-2-en-1-one
• CAS: 1308887-12-8
• 化学式: C₁₉H₂₂O₄
• 分子量: 314.381
• InChiKey: OGHQXJFAZQXMJC-JXMROGBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-methoxy-2-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-5,5-dimethylcyclohex-2-en-1-one 以 氯仿 、 甲苯 为溶剂， 生成 2-(4-methoxyphenyl)-7,7-dimethyl-1-(4-methylphenyl)-1,2,3,4,5,6,7,8-octahydroquinoline-4,5-dione
  参考文献：
  名称：

  Synthesis of exo- and endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones

  摘要：

  Condensation of 2-acetylcyclohexane-1,3-diones with aromatic aldehydes in the presence of piperidine, pyrrolidine, hexamethyleneimine, or morpholine gave the corresponding 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones as the major products and 2-[3-aryl-1-cycloalkylaminoprop-2-en-1-ylidene]cyclohexane1,3-diones as minor ones. Endocyclic enamino derivatives were synthesized in two steps through enol methyl ethers which reacted with amines. Endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl) cyclohexane-1,3-diones containing an aryl group on the nitrogen atom readily underwent cyclization to 1,2,3,4,5,6,7,8-octa-hydroquinoline-4,5-dione derivatives.

  DOI：

  10.1134/s1070428011030018
• 作为产物：
  描述：

  2-乙酰基-5,5-二甲基-1,3-环己二酮 在 potassium carbonate 作用下， 以 甲苯 为溶剂， 生成 3-methoxy-2-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-5,5-dimethylcyclohex-2-en-1-one
  参考文献：
  名称：

  Synthesis of exo- and endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones

  摘要：

  Condensation of 2-acetylcyclohexane-1,3-diones with aromatic aldehydes in the presence of piperidine, pyrrolidine, hexamethyleneimine, or morpholine gave the corresponding 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones as the major products and 2-[3-aryl-1-cycloalkylaminoprop-2-en-1-ylidene]cyclohexane1,3-diones as minor ones. Endocyclic enamino derivatives were synthesized in two steps through enol methyl ethers which reacted with amines. Endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl) cyclohexane-1,3-diones containing an aryl group on the nitrogen atom readily underwent cyclization to 1,2,3,4,5,6,7,8-octa-hydroquinoline-4,5-dione derivatives.

  DOI：

  10.1134/s1070428011030018

文献信息

• Synthesis of exo- and endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones
  作者：D. B. Rubinov、I. L. Rubinova、F. A. Lakhvich

  DOI：10.1134/s1070428011030018

  日期：2011.3

  Condensation of 2-acetylcyclohexane-1,3-diones with aromatic aldehydes in the presence of piperidine, pyrrolidine, hexamethyleneimine, or morpholine gave the corresponding 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones as the major products and 2-[3-aryl-1-cycloalkylaminoprop-2-en-1-ylidene]cyclohexane1,3-diones as minor ones. Endocyclic enamino derivatives were synthesized in two steps through enol methyl ethers which reacted with amines. Endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl) cyclohexane-1,3-diones containing an aryl group on the nitrogen atom readily underwent cyclization to 1,2,3,4,5,6,7,8-octa-hydroquinoline-4,5-dione derivatives.