2,6-dimethoxy-4-{2-[5-(1,1,2,2-tetramethyl-1-silapropoxy)cyclohexa-1,4-dienyl]ethyl}phenol | 731849-04-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2,6-dimethoxy-4-{2-[5-(1,1,2,2-tetramethyl-1-silapropoxy)cyclohexa-1,4-dienyl]ethyl}phenol
• CAS: 731849-04-0
• 化学式: C₂₂H₃₄O₄Si
• 分子量: 390.595
• InChiKey: BQDGWUVHNSAMIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.97
• 重原子数：
  27.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  47.92
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2,6-dimethoxy-4-{2-[5-(1,1,2,2-tetramethyl-1-silapropoxy)cyclohexa-1,4-dienyl]ethyl}phenol 在 盐酸 、 二乙胺基三氟化硫 、 碘 、 对甲苯磺酸 、 magnesium 、 间氯过氧苯甲酸 作用下， 以 甲醇 、 乙二醇二甲醚 、 乙醚 、 二氯甲烷 、 水 、 苯 为溶剂， 反应 87.0h， 生成
  参考文献：
  名称：

  Synthesis and antimicrotubule activity of combretatropone derivatives

  摘要：

  Combretatropone is a hybrid of combretastatin and colchicine in which the a-methoxyphenol of dihydrocombretastatin A-4 is replaced by an alpha-methoxytropone. Derivatives of combretatropone have been synthesized and evaluated for antimicrotubule activity. All combretatropones were less active than the corresponding colchicine derivatives, supporting the idea that loss of ligand conformational entropy upon tubulin binding results in decreased potency for colchicinoid ligands. The structure-activity relationship of the combretatropone series was different than that of the colchicine series. These data indicate that conformationally mobile and conformationally rigid colchicinoids do not interact with the receptor site in the same manner. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00052-4
• 作为产物：
  描述：

  2,6-dimethoxy-4-{2-[3-(1,1,2,2-tetramethyl-1-silapropoxy)phenyl]ethyl}phenol 在 氨 、 lithium 、 叔丁醇 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以90%的产率得到2,6-dimethoxy-4-{2-[5-(1,1,2,2-tetramethyl-1-silapropoxy)cyclohexa-1,4-dienyl]ethyl}phenol
  参考文献：
  名称：

  Synthesis and antimicrotubule activity of combretatropone derivatives

  摘要：

  Combretatropone is a hybrid of combretastatin and colchicine in which the a-methoxyphenol of dihydrocombretastatin A-4 is replaced by an alpha-methoxytropone. Derivatives of combretatropone have been synthesized and evaluated for antimicrotubule activity. All combretatropones were less active than the corresponding colchicine derivatives, supporting the idea that loss of ligand conformational entropy upon tubulin binding results in decreased potency for colchicinoid ligands. The structure-activity relationship of the combretatropone series was different than that of the colchicine series. These data indicate that conformationally mobile and conformationally rigid colchicinoids do not interact with the receptor site in the same manner. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00052-4