4-Methyl-1,3-dihydrofuro[3,4-c]pyridine | 936371-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-Methyl-1,3-dihydrofuro[3,4-c]pyridine
• CAS: 936371-92-5
• 化学式: C₈H₉NO
• 分子量: 135.166
• InChiKey: XBBDELRALZNXKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-oxanona-2,7-diyn-1-ol 在 cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate 丙二酸 、 盐酸羟胺 、 sodium acetate 作用下， 以 乙醇 、 水 、 丙酮 为溶剂， 反应 1.0h， 生成 4-Methyl-1,3-dihydrofuro[3,4-c]pyridine
  参考文献：
  名称：

  Ruthenium-Catalyzed Cycloisomerization−6π-Cyclization:  A Novel Route to Pyridines

  摘要：

  Herein we report a method for the synthesis of substituted pyridines. The unsaturated ketones and aldehydes derived from the cycloisomerization of primary and secondary propargyl diynols in the presence of [CpRu(CH3CN)(3)]PF6 (1) are converted to 1-azatrienes which in turn undergo a subsequent electrocyclization-dehydration to provide pyridines with excellent regiocontrol.

  DOI：

  10.1021/ol070163t

文献信息

• Piperidine compounds as PCSK9 inhibitors
  申请人：SHENZHEN SALUBRIS PHARM CO LTD

  公开号：US10513514B2

  公开（公告）日：2019-12-24

  One aspect of the invention relates to a series of new PCSK9 inhibitor compounds comprising piperidine ring structures, including compounds of formula (I) and/or pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating PCSK9 receptor related diseases comprising administration of one or more compounds of formula (I) or a pharmaceutically acceptable salt thereof.

  本发明的一个方面涉及一系列新的包含哌啶环结构的PCSK9抑制剂化合物，包括式（I）化合物和/或其药学上可接受的盐。本发明的另一方面涉及治疗 PCSK9 受体相关疾病的方法，包括施用一种或多种式（I）化合物或其药学上可接受的盐。
• Ruthenium-Catalyzed Cycloisomerization−6π-Cyclization:  A Novel Route to Pyridines
  作者：Barry M. Trost、Alicia C. Gutierrez

  DOI：10.1021/ol070163t

  日期：2007.4.1

  Herein we report a method for the synthesis of substituted pyridines. The unsaturated ketones and aldehydes derived from the cycloisomerization of primary and secondary propargyl diynols in the presence of [CpRu(CH3CN)(3)]PF6 (1) are converted to 1-azatrienes which in turn undergo a subsequent electrocyclization-dehydration to provide pyridines with excellent regiocontrol.