N,N-diethyl(3-fluorobenzyl)amine | 140401-60-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-diethyl(3-fluorobenzyl)amine
• 英文别名: N-ethyl-N-[(3-fluorophenyl)methyl]ethanamine
• CAS: 140401-60-1
• 化学式: C₁₁H₁₆FN
• 分子量: 181.253
• InChiKey: WAZPDMSGKRPWLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二乙胺 、 间氟氯苄 以 甲苯 为溶剂， 生成 N,N-diethyl(3-fluorobenzyl)amine
  参考文献：
  名称：

  替代作用。14.水-有机溶剂混合物中的离解常数异常：苄基铵离子和相关系统

  摘要：

  给出了对于苄基铵，苄基二烷基铵和（2-苯乙基）铵离子的各种水-有机溶剂混合物中的热力学解离常数。与Hammett方程（方程式1）的偏差与对羧酸观察到的偏差相似，但符号相反。包含疏水常数π的扩展Hammett方程（等式3）产生了良好的相关性。举例说明了派生的次级正常sigma值。

  DOI：

  10.1002/recl.19921110103

文献信息

• Simple Metal-Free Direct Reductive Amination Using Hydrosilatrane to Form Secondary and Tertiary Amines
  作者：Sami E. Varjosaari、Vladislav Skrypai、Paolo Suating、Joseph J. M. Hurley、Ashley M. De Lio、Thomas M. Gilbert、Marc J. Adler

  DOI：10.1002/adsc.201700079

  日期：2017.6.6

  This work describes the use of cheap, safe, and easy-to-handle hydrosilatrane as the reductant in direct reductive amination reactions. This efficient method enables a facile, metal-free access to secondary and tertiary amines from a wide range of aldehydes and ketones, with the synthesis of tertiary amines requiring no additives at all. This reaction demonstrates excellent functional group tolerance

  这项工作描述了在直接还原胺化反应中使用便宜，安全且易于操作的氢化硅环烷作为还原剂。这种高效的方法可以轻松，无金属地从各种醛和酮中获得仲胺和叔胺，而叔胺的合成则完全不需要添加剂。该反应显示出优异的官能团耐受性，化学选择性和可扩展性。
• Transition metal complex ligand and olefin polymerization catalyst containing transition metal complex
  申请人：Otomaru Yuka

  公开号：US20070135600A1

  公开（公告）日：2007-06-14

  The invention provides a transition metal complex of formula (3) below: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are the same or different and each independently represents a hydrogen atom, a halogen atom or a substituted or unsubstituted alkyl group having 1 to 10 carbon atom(s); R 5 represents a hydrogen atom, a fluorine atom or a substituted or unsubstituted alkyl group having 1 to 10 carbon atom(s); X 1 represents a hydrogen atom, a halogen atom or a substituted or unsubstituted alkyl group having 1 to 10 carbon atom(s); L represents a balancing counter ion or neutral ligand similar to X 1 that is bonding or coordinating to metal M; and q represents an integer of 0 or 1, and G 20 represents any one of G 21 to G 26 below: where A 1 represents an element of Group 15 of the periodic table, wherein A 1 in G 23 represents an anion of an element of Group 15 of the periodic table, and A 1 in G 21 represents a nitrogen atom; R 9 , R 14 , R 12 , R 13 , R 19 , R 20 , R 10 , R 11 , R 15 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 and R 22 each independently represents, a hydrogen atom; or a substituted or unsubstituted alkyl groups having 1 to 10 carbon atom(s), and the line linking M and R 20 represents that M is coordinated or linked to an element of Group 15 or 16 of the periodic table or to a fluorine atom constituting R 20 .
• US7482414B2
  申请人：——

  公开号：US7482414B2

  公开（公告）日：2009-01-27
• US7915455B2
  申请人：——

  公开号：US7915455B2

  公开（公告）日：2011-03-29