2,4-二甲基-6,7-二氢-苯并呋喃 | 103261-89-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 中文名称: 2,4-二甲基-6,7-二氢-苯并呋喃
• 英文名称: 2,4-dimethyl-6,7-dihydro-benzofuran
• 英文别名: 2,4-Dimethyl-6,7-dihydro-1-benzofuran；2,4-dimethyl-6,7-dihydro-1-benzofuran
• CAS: 103261-89-8
• 化学式: C₁₀H₁₂O
• 分子量: 148.205
• InChiKey: BOMAVDVPCJAELL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.94
• 重原子数：
  11.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  13.14
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  甲硫醇钠 在 对甲苯磺酸 作用下， 以 乙醚 、 xylene 为溶剂， 反应 8.0h， 生成 2,4-二甲基-6,7-二氢-苯并呋喃
  参考文献：
  名称：

  The fischer indolisation reaction and the synthesis of dihydroindenoindoles

  摘要：

  The Fischer reaction between indanones and certain alkoxyarylhydrazines fails; the indanones are returned unreacted and the arylhydrazines are converted into the corresponding alkoxy-2-chloroarylamines and other products. A new N-amination route to arylhydrazines from the arylamines has been developed and it has been demonstrated that problems with the indolisation of alkoxyarylhydrazones can be circumvented by ring closures of their O-tosylated analogues. Some results using the Lepke synthesis of indoles are recorded.

  DOI：

  10.1016/s0040-4020(01)81911-6

文献信息

• Taylor, Journal of the Chemical Society, 1950, p. 2767
  作者：Taylor

  DOI：——

  日期：——
• The fischer indolisation reaction and the synthesis of dihydroindenoindoles
  作者：David W. Brown、Mary F. Mahon、Aleyamma Ninan、Malcolm Sainsbury、Howard G. Shertzer

  DOI：10.1016/s0040-4020(01)81911-6

  日期：1993.1

  The Fischer reaction between indanones and certain alkoxyarylhydrazines fails; the indanones are returned unreacted and the arylhydrazines are converted into the corresponding alkoxy-2-chloroarylamines and other products. A new N-amination route to arylhydrazines from the arylamines has been developed and it has been demonstrated that problems with the indolisation of alkoxyarylhydrazones can be circumvented by ring closures of their O-tosylated analogues. Some results using the Lepke synthesis of indoles are recorded.