Ethyl (NE)-N-(phenylcarbamoylimino)carbamate | 131290-11-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl (NE)-N-(phenylcarbamoylimino)carbamate
• CAS: 131290-11-4
• 化学式: C₁₀H₁₁N₃O₃
• 分子量: 221.216
• InChiKey: KWINRRDXXHOJNB-OUKQBFOZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  80.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Ethyl (NE)-N-(phenylcarbamoylimino)carbamate 在 thiol 作用下， 以 丙酮 、 乙腈 为溶剂， 生成 1-[2-(Dimethylamino)ethyl]-3-(phenylcarbamoylamino)urea
  参考文献：
  名称：

  Diazenedicarboxamides as inhibitors of d-alanine-d-alanine ligase (Ddl)

  摘要：

  D-Alanine-D-alanine ligase (Ddl) catalyzes the biosynthesis of an essential bacterial peptidoglycan precursor D-alanyl-D-alanine and it represents an important target for development of new antibacterial drugs. A series of semicarbazides, aminocarbonyldiazenecarboxylates, diazenedicarboxamides, and hydrazinedicarboxamides was synthesized and screened for inhibition of DdlB from Escherichia coli. Compounds with good inhibitory activity were identified, enabling us to deduce initial structure-activity relationships. Thirteen diazenedicarboxamides were better inhibitors than D-cycloserine and some of them also possess antibacterial activity, which makes them a promising starting point for further development. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.01.015
• 作为产物：
  描述：

  2-[(苯基氨基)羰基]-肼羧酸乙酯 在 吡啶 、 N-溴代丁二酰亚胺(NBS) 作用下， 以 二氯甲烷 为溶剂， 生成 Ethyl (NE)-N-(phenylcarbamoylimino)carbamate
  参考文献：
  名称：

  Diazenedicarboxamides as inhibitors of d-alanine-d-alanine ligase (Ddl)

  摘要：

  D-Alanine-D-alanine ligase (Ddl) catalyzes the biosynthesis of an essential bacterial peptidoglycan precursor D-alanyl-D-alanine and it represents an important target for development of new antibacterial drugs. A series of semicarbazides, aminocarbonyldiazenecarboxylates, diazenedicarboxamides, and hydrazinedicarboxamides was synthesized and screened for inhibition of DdlB from Escherichia coli. Compounds with good inhibitory activity were identified, enabling us to deduce initial structure-activity relationships. Thirteen diazenedicarboxamides were better inhibitors than D-cycloserine and some of them also possess antibacterial activity, which makes them a promising starting point for further development. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.01.015

文献信息

• Diazenedicarboxamides as inhibitors of D-alanine: D-alanine ligase (Ddl)
  申请人：University of Ljubljana

  公开号：EP1889831A2

  公开（公告）日：2008-02-20

  This invention belongs to the field of pharmaceutical chemistry and relates to new diazenedicarboxamides as inhibitors of D-alanine:D-alanine ligaze (Ddl), to procedures for their preparation and pharmaceutical preparations containing the same. Compounds of general formula I: and the pharmaceutically acceptable salts are described. The appropriate substituents are clearly presented in the body of the text and in claims.

  本发明属于药物化学领域，涉及作为 D-丙氨酸：D-丙氨酸连接酶（Ddl）抑制剂的新重氮二 羧酰胺、其制备程序和含有这些化合物的药物制剂。通式 I 的化合物： 及其药学上可接受的盐类。适当的取代基在正文和权利要求中均有明确表述。
• Storable gas generating compositions
  申请人：Saudi Arabian Oil Company

  公开号：US10590326B1

  公开（公告）日：2020-03-17

  The present application provides an aqueous fluid containing a gas-generating compound such as an azo compound, a hydrazide compound, or a semicarbazide compound. The aqueous fluid may also contain an amine compound, an oxidizer, or viscosifier, and a foaming surfactant. The aqueous composition may be storable at pH of less than about 5 without any appreciable gas generation, and may be activated to produce gas when mixed with a wellbore fluid for use in downhole applications.

  本申请提供了一种含气化合物（如偶氮化合物、酰肼化合物或半咔嗪化合物）的水基流体。该水性流体还可含有胺化合物、氧化剂或增粘剂以及发泡表面活性剂。水性组合物在 pH 值小于 5 时可储存，不会产生明显的气体，当与井筒流体混合用于井下应用时，可活化产生气体。
• Gas generating compositions
  申请人：Saudi Arabian Oil Company

  公开号：US10858565B2

  公开（公告）日：2020-12-08

  The present application provides a gas-generating aqueous fluid containing a gas-generating compound like an azo compound, and an organic amine like a primary, secondary or tertiary amine, a hydrazine, a hydrazide, or a semicarbazide. The aqueous fluid may also a viscosifier, and a foaming surfactant. The present application also provides a method of using the gas-generating composition to modulate density of a wellbore fluid for use in downhole applications. The method optionally includes adding an oxidizer to the wellbore fluid.

  本申请提供了一种可产生气体的水性流体，其中含有偶氮化合物等可产生气体的化合物，以及伯胺、仲胺或叔胺、肼、肼酰胺或半肼等有机胺。水性流体还可以是增粘剂和发泡表面活性剂。本申请还提供了一种使用气体生成组合物调节井下应用中井筒流体密度的方法。该方法可选地包括向井筒流体中添加氧化剂。
• KASPER, F.;MEYER, P.
  作者：KASPER, F.、MEYER, P.

  DOI：——

  日期：——
• GAS GENERATING COMPOSITIONS
  申请人：Saudi Arabian Oil Company

  公开号：US20200270502A1

  公开（公告）日：2020-08-27

  The present application provides a gas-generating aqueous fluid containing a gas-generating compound like an azo compound, and an organic amine like a primary, secondary or tertiary amine, a hydrazine, a hydrazide, or a semicarbazide. The aqueous fluid may also a viscosifler, and a foaming surfactant. The present application also provides a method of using the gas-generating composition to modulate density of a wellbore fluid for use in downhole applications. The method optionally includes adding an oxidizer to the wellbore fluid.