ganciclovir | 84960-04-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: ganciclovir
• 英文别名: 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-1H-purin-6-one；9-(1,3-dihydroxypropan-2-yloxymethyl)-1H-purin-6-one
• CAS: 84960-04-3
• 化学式: C₉H₁₂N₄O₄
• 分子量: 240.219
• InChiKey: INKMBQHLIDNGHQ-UHFFFAOYSA-N

物化性质

• 沸点：
  690.6±50.0 °C(Predicted)
• 密度：
  1.67±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>-6-methoxypurine 在 sodium hydroxide 、 三氯化硼 作用下， 以 水 为溶剂， 反应 0.5h， 生成 ganciclovir
  参考文献：
  名称：

  抗病毒化合物的合成。6-甲氧基甘油嘌呤的制备与重排

  摘要：

  合成这些d'[羟基-2'羟甲基-1'乙氧基甲基]-9（=R-9）甲氧基-6嘌呤和d'氨基-2甲氧基-6 R-7-ou-R-9嘌呤部分取代衍生出氯-6 通讯员。转座异构体 R-7 en 异构体 R-9

  DOI：

  10.1139/v84-459

文献信息

• Synthesis of a purine acyclonucleoside series having pronounced antiviral activity. The glyceropurines
  作者：Kelvin K. Ogilvie、Nghe Nguyen-Ba、Michael F. Gillen、Bruno K. Radatus、Ukken O. Cheriyan、H. Rizk Hanna、Kendall O. Smith、Karen S. Galloway

  DOI：10.1139/v84-039

  日期：1984.2.1

  The synthesis of a series of purine analogues of the acyclonucleoside compound A* (A-Star, 1) is described. Compounds in this series have been shown to have pronounced activity against herpesviruses. These compounds have been designated "the glycerosides". The glyceropurines are described in this report. Nucleotides have been constructed containing glyceroadenine (A*, compound 1). These nucleotides are resistant to degradation by phosphodiesterases. The compound A* is both a poor substrate and a poor inhibitor of adenosine deaminase.

  描述了一系列嘌呤类似物A*（A-Star，1）的无环核苷化合物的合成。该系列化合物已被证明对疱疹病毒具有显著的活性。这些化合物被命名为“甘油苷”。本报告描述了甘油嘌呤。已构建含有甘油腺嘌呤（A*，化合物1）的核苷酸，这些核苷酸对磷酸二酯酶的降解具有抵抗性。化合物A*既是腺苷脱氨酶的劣质底物，也是劣质抑制剂。
• PHOTOCLEAVABLE LABELED NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN IN DNA SEQUENCING
  申请人：WU Weidong

  公开号：US20130072388A1

  公开（公告）日：2013-03-21

  Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide or nucleoside with an unprotected 3′-OH group is derivatized at the nucleobase to include a fluorescent dye attached via a linker to a photocleavable terminating group. The photocleavable-fluorescent group is designed to terminate DNA synthesis as well as be cleaved so that DNA oligomers can be sequenced efficiently in a parallel format. The design of such rapidly cleavable fluorescent groups on nucleotides and nucleosides can enhance the speed and accuracy of sequencing of large oligomers of DNA in parallel, to allow rapid whole genome sequencing, and the identification of polymorphisms and other valuable genetic information, as well as allowing further manipulation and analysis of nucleic acid molecules in their native state following cleavage of the fluorescent group.

  本文介绍了新型核苷酸、核苷和其衍生物，可用于DNA测序技术和其他类型的DNA分析。在一个实施例中，未保护的3'-OH基团的核苷酸或核苷被衍生化，以在核碱基上包含通过连接剂连接到光解可断裂终止基团的荧光染料。光解可断裂的荧光基团被设计为终止DNA合成，并被裂解，以便在并行格式中高效地对DNA寡聚物进行测序。在核苷酸和核苷上设计这种快速可裂解的荧光基团，可以增强大型DNA寡聚物并行测序的速度和准确性，以实现快速的全基因组测序，并识别多态性和其他有价值的遗传信息，同时允许在裂解荧光基团后进一步操作和分析核酸分子的原生状态。
• US8969535B2
  申请人：——

  公开号：US8969535B2

  公开（公告）日：2015-03-03
• Synthesis of antiviral compounds. Preparation and rearrangement of 6-methoxyglyceropurines
  作者：Kelvin K. Ogilvie、H. Rizk Hanna

  DOI：10.1139/v84-459

  日期：1984.12.1

  Synthese d'[hydroxy-2' hydroxymethyl-1' ethoxymethyl]-9 (=R-9) methoxy-6 purine et d'amino-2 methoxy-6 R-7- ou -R-9 purines par substitution des derives chloro-6 correspondants. Transposition des isomeres R-7 en isomeres R-9

  合成这些d'[羟基-2'羟甲基-1'乙氧基甲基]-9（=R-9）甲氧基-6嘌呤和d'氨基-2甲氧基-6 R-7-ou-R-9嘌呤部分取代衍生出氯-6 通讯员。转座异构体 R-7 en 异构体 R-9