phenoxyacetic-d2 acid | 19215-15-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: phenoxyacetic-d2 acid
• 英文别名: 2,2-Dideuterio-2-phenoxy-essigsaeure；Phenoxyessigsaeure-α,α-d(2)；Phenoxyessigsaeure-2,2-d(2)；2,2-dideuterio-2-phenoxy-acetic acid；2-Phenoxyacetic-2,2-D2 acid；2,2-dideuterio-2-phenoxyacetic acid
• CAS: 19215-15-7
• 化学式: C₈H₈O₃
• 分子量: 154.134
• InChiKey: LCPDWSOZIOUXRV-NCYHJHSESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.15
• 重原子数：
  11.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  phenoxyacetic-d2 acid 在 lithium aluminium tetrahydride 作用下， 生成 2-Phenoxyethyl-2,2-D2 alcohol
  参考文献：
  名称：

  Nguyen, Viet; Cheng, Xueheng; Morton, Thomas, Journal of the American Chemical Society, 1992, vol. 114, # 18, p. 7127 - 7132

  摘要：

  DOI：
• 作为产物：
  描述：

  溴乙酸-d3 、 苯酚 生成 phenoxyacetic-d2 acid
  参考文献：
  名称：

  Skeletal rearrangements preceding CO loss from metastable phenoxymethylene ions derived from phenoxyacetic acid and anisole

  摘要：

  AbstractThe loss of CH2˙ from the molecular ion of phenoxyacetic acid and the expulsion of an H˙ atom from ionized anisole lead to phenoxymethylen ions, which fragment predominantly by CO loss on the microsecond time‐scale. Carbon‐13 labelling reveals that ∼90% of the CO molecules expelled from the metastable ions derived from phenoxyacetic acid incorporate the carbon atom from the 1‐position of the phenyl group of the parent compound, whereas the residual CO molecules contain one of the other carbon atoms of the aromatic ring. The 2‐fluoro‐ and 2‐methylphenoxymethylene ions derived from the appropriate aryloxyacetic acids behave similarly, i.e. the carbon atom of the methylene group of the parent compound is not incorporated in the expelled CO molecules. In contrast, ∼45% of the CO molecules eliminated from the metastable phenoxymethylene ions formed from ionized anisole contain the carbon atom of the methyl group, while the remaining part contains the carbon atom from the 1‐position of the phenyl ring of the parent compound. This result is taken as evidence for the occurrence of a skeletal rearrangement of the anisole molecular ion leading to an interchange between the carbon atom of the methyl group and the carbon atom at the 1‐position of the ring. The elimination of CO from the metastable ions generated from either phenoxyacetic acid or anisole gives rise to a composite metastable peak. Conclusive evidence as to the formation of [C7H7O]+ isomers other than the phenoxymethylene ion is not obtained, indicating that the composite metastable peak is a result of two competing reactions both leading to CO loss. Possible mechanisms of these reactions are discussed together with the mechanism of the skeletal rearrangement of the molecular ion of anisole prior to H˙ loss.

  DOI：

  10.1002/oms.1210281031