(3R)-3-(pent-4-enoylamino)-3-phenylpropanoic acid | 480443-46-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3R)-3-(pent-4-enoylamino)-3-phenylpropanoic acid
• CAS: 480443-46-7
• 化学式: C₁₄H₁₇NO₃
• 分子量: 247.294
• InChiKey: VEKZXAJEOWISQD-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3R)-3-(pent-4-enoylamino)-3-phenylpropanoic acid 在 Grubbs catalyst first generation 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Synthesis of a cyclic pseudo 310 helical structure from a β-amino acid-l-proline derived tripeptide via a ring closing metathesis reaction

  摘要：

  The combination of homo-phenylglycine (Hpg) and proline leads to the formation of a beta-turn mimic, which can be transformed into a cyclic peptide using a ring closing metathesis reaction. The presence of the pentenoyl and allyl groups at the terminus of the peptide leads to the concomitant formation of a linker surrogate fourth amino acid (6-amino-4-hexenoic acid; Aha) during the cyclization. The cyclic peptide is unique in having a pseudo 3(10) helical structure. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01239-x
• 作为产物：
  描述：

  Pent-4-enoic acid ((S)-3-diazo-2-oxo-1-phenyl-propyl)-amide 在 lithium hydroxide 、 silver(I) acetate 、 三乙胺 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 (3R)-3-(pent-4-enoylamino)-3-phenylpropanoic acid
  参考文献：
  名称：

  Synthesis of a cyclic pseudo 310 helical structure from a β-amino acid-l-proline derived tripeptide via a ring closing metathesis reaction

  摘要：

  The combination of homo-phenylglycine (Hpg) and proline leads to the formation of a beta-turn mimic, which can be transformed into a cyclic peptide using a ring closing metathesis reaction. The presence of the pentenoyl and allyl groups at the terminus of the peptide leads to the concomitant formation of a linker surrogate fourth amino acid (6-amino-4-hexenoic acid; Aha) during the cyclization. The cyclic peptide is unique in having a pseudo 3(10) helical structure. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01239-x

文献信息

• Method For Enrichment Involving Elimination By Mismatch Hybridisation
  申请人：Freskgard Per-Ola

  公开号：US20090239211A1

  公开（公告）日：2009-09-24

  The present invention relates to a method for selecting a molecule from a library of such molecules associated with identifier oligonucleotides, said molecule having affinity towards a target. The method involves contacting library with a target to allow for an interaction between the molecules and the target and partitioning a fraction enriched in identifier oligonucleotides of molecules interacting with the target. After an optional nucleic acid amplification of the partitioned fraction, the fraction is subjected to conditions at which hetero-duplexes and homo-duplexes are formed. The homo-duplexes are subsequently recovered and decoded to identify the identity of the molecule interacting with the target.
• Synthesis of a cyclic pseudo 310 helical structure from a β-amino acid-l-proline derived tripeptide via a ring closing metathesis reaction
  作者：Biswadip Banerji、B Mallesham、S Kiran Kumar、A.C Kunwar、Javed Iqbal

  DOI：10.1016/s0040-4039(02)01239-x

  日期：2002.9

  The combination of homo-phenylglycine (Hpg) and proline leads to the formation of a beta-turn mimic, which can be transformed into a cyclic peptide using a ring closing metathesis reaction. The presence of the pentenoyl and allyl groups at the terminus of the peptide leads to the concomitant formation of a linker surrogate fourth amino acid (6-amino-4-hexenoic acid; Aha) during the cyclization. The cyclic peptide is unique in having a pseudo 3(10) helical structure. (C) 2002 Elsevier Science Ltd. All rights reserved.