2-(2-氯苯氧基)乙胺盐酸盐 | 26378-54-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2-(2-氯苯氧基)乙胺盐酸盐
• 英文名称: 2-(2-Chlorophenoxy)ethanamine hydrochloride
• 英文别名: 2-(2-chlorophenoxy)ethanamine;hydrochloride
• CAS: 26378-54-1
• 化学式: C₈H₁₀ClNO*ClH
• 分子量: 208.087
• InChiKey: WHGGIYJUHBWONH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2922299090

反应信息

• 作为反应物：
  描述：

  苯基缩水甘油醚 、 2-(2-氯苯氧基)乙胺盐酸盐 在 sodium hydroxide 作用下， 以 丙醇 为溶剂， 生成 1-[2-(2-Chloro-phenoxy)-ethylamino]-3-phenoxy-propan-2-ol
  参考文献：
  名称：

  .beta.-Adrenergic blocking agents. 17. 1-Phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propanols

  摘要：

  The synthesis is described of a series of derivatives of 1-phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propranols. The compounds were investigated for their beta-adrenoceptor blocking properties and many showed a surprising degree of cardioselectivity when tested in vivo in anesthetized cats for their effects on an isoproterenol-induced tachycardia and depressor response. The structure-activity relationship shown by this series of compounds is related to that of known cardioselective analogues and a possible reason for their cardioselectivity is discussed.

  DOI：

  10.1021/jm00222a022

文献信息

• Phenoxypropanol connected with phenylpiperazine and phenoxyalkylamine terminal in its side chain
  申请人：——

  公开号：US20030055066A1

  公开（公告）日：2003-03-20

  The invention disclosed some 1,4-dihydropiridine derivative chemically have pharmacologically with adrenoceptor blocking and calcium channel blocker is now emerging. The compound of 1,4-dihydropiridine derivative wherein has the formula I, wherein R selected from four group as follow 1 whetherin R present R 1 selected from halogen(X), hydrogen(H), saturated C 1 -C 6 alkyl chain, saturated C 1 -C 6 alkyoxyl chain, R 2 selected from 2 R 3 selected from halogen(X), hydrogen(H), saturated C 1 -C 6 alkyl chain, saturated C 1 -C 6 alkyoxyl chain, and O—(C 1 -C 3 )—CF 3 .

  该发明披露了一些具有肾上腺素受体阻滞和钙通道阻滞药理作用的1,4-二氢吡啶衍生物化合物正在出现。其中1,4-二氢吡啶衍生物化合物的化学式为I，其中R选自以下四个基团之一：1. 在R存在时，R1选自卤素（X），氢（H），饱和C1-C6烷基链，饱和C1-C6烷氧基链，R2选自2，R3选自卤素（X），氢（H），饱和C1-C6烷基链，饱和C1-C6烷氧基链，和O-(C1-C3)-CF3。
• DE1913199
  申请人：——

  公开号：——

  公开（公告）日：——
• US6846826B2
  申请人：——

  公开号：US6846826B2

  公开（公告）日：2005-01-25
• .beta.-Adrenergic blocking agents. 17. 1-Phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propanols
  作者：L. H. Smith、H. Tucker

  DOI：10.1021/jm00222a022

  日期：1977.12

  The synthesis is described of a series of derivatives of 1-phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propranols. The compounds were investigated for their beta-adrenoceptor blocking properties and many showed a surprising degree of cardioselectivity when tested in vivo in anesthetized cats for their effects on an isoproterenol-induced tachycardia and depressor response. The structure-activity relationship shown by this series of compounds is related to that of known cardioselective analogues and a possible reason for their cardioselectivity is discussed.