2-Dimethylamino-propionsaeure-methylamid | 89909-95-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Dimethylamino-propionsaeure-methylamid
• 英文别名: 2-(dimethylamino)-N-methylpropanamide
• CAS: 89909-95-5
• 化学式: C₆H₁₄N₂O
• mdl: MFCD19159687
• 分子量: 130.19
• InChiKey: RGBPJHSWUVULDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Dimethylamino-propionsaeure-methylamid 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 N1,N2,N2-三甲基-1,2-丙烷二胺
  参考文献：
  名称：

  止痛药。α-烷氧基二苯甲酸的碱性酰胺。

  摘要：

  DOI：

  10.1021/jm00341a018
• 作为产物：
  描述：

  N-methyl-2-bromopropanamide 、 二甲胺 以 苯 为溶剂， 生成 2-Dimethylamino-propionsaeure-methylamid
  参考文献：
  名称：

  止痛药。α-烷氧基二苯甲酸的碱性酰胺。

  摘要：

  DOI：

  10.1021/jm00341a018

文献信息

• Novel Isobaric Tandem Mass Tags for Quantitative Proteomics and Peptidomics
  申请人：Li Lingjun

  公开号：US20130078728A1

  公开（公告）日：2013-03-28

  Compositions and methods of tagging peptides and other molecules using novel isobaric tandem mass tagging reagents, including novel N,N-dimethylated amino acid 8-plex and 16-plex isobaric tandem mass tagging reagents. The tagging reagents comprise: a) a reporter group having at least one atom that is optionally isotopically labeled; b) a balancing group, also having at least one atom that is optionally isotopically labeled, and c) an amine reactive group. The tagging reagents disclosed herein serve as attractive alternatives for isobaric tag for relative and absolute quantitation (iTRAQ) and tandem mass tags (TMTs) due to their synthetic simplicity, labeling efficiency and improved fragmentation efficiency.

  使用新型等比串联质谱标记试剂标记肽和其他分子的组合物和方法，包括新型N,N-二甲基化氨基酸8-plex和16-plex等比串联质谱标记试剂。这些标记试剂包括：a）至少有一个原子可选择同位素标记的报告基团；b）至少有一个原子可选择同位素标记的平衡基团；以及c）胺基反应基团。本文披露的标记试剂作为等比标记相对和绝对定量（iTRAQ）和串联质谱标记（TMTs）的吸引人的替代品，由于其合成简单性、标记效率和改善的碎裂效率。
• CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
  申请人：Cytokinetics, Inc.

  公开号：EP1962846A2

  公开（公告）日：2008-09-03
• DERIVATIVES OF AMPHOTERICIN B
  申请人：Sfunga Therapeutics, Inc.

  公开号：EP3283171B1

  公开（公告）日：2021-05-26
• Pharmacokinetically Improved Compounds
  申请人：Campbell Stewart

  公开号：US20080176844A1

  公开（公告）日：2008-07-24

  A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or pharmaceutically acceptable salt, stereoisomer, or hydrate thereof, wherein R 1 is lower alkyl, R 2 and R 3 are independently selected from lower alkyl, and lower alkenyl and lower alkynyl, wherein the lower alkyl, lower alkenyl, and lower alkynyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO 2 , amino, acylamino, amido, carbonyl, and alkylthio, A is N or C—H, B is N, C—H, C—(SO 2 —R 4 ), or C—CO—R 4 , D is N, C—H, C—(SO 2 —R 4 ) or C—CO—R 4 , E is N or C—H, wherein only one of A, B or E may be N, and one of B or D is C—(SO 2 —R 4 ) or C—CO—R 4 , R 4 is a group having the formula: in which each R 5 , R 6 , R 7 and R 8 are independently selected from H and lower alkyl, wherein the lower alkyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO 2 , amino, acylamino, amido, carbonyl, and alkylthio; and additionally or alternatively R 6 and R 5 together form a 5- or 6-membered ring, or R 6 and R 7 together form a 3 to 6 membered ring; R 9 is independently selected from H and lower alkyl, wherein the lower alkyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO 2 , amino, acylamino, amido, carbonyl, and alkylthio; alternatively R 8 and R 9 together with the nitrogen to which they are attached form a 5- or 6-membered ring; n is 1 to 4; and m is 1 to 6.
• PHARMACOKINETICALLY IMPROVED COMPOUNDS
  申请人：CAMPBELL Stewart

  公开号：US20100093719A1

  公开（公告）日：2010-04-15

  A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or pharmaceutically acceptable salt, stereoisomer, or hydrate thereof, wherein R 1 is lower alkyl, R 2 and R 3 are independently selected from lower alkyl, and lower alkenyl and lower alkynyl, wherein the lower alkyl, lower alkenyl, and lower alkynyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO 2 , amino, acylamino, amido, carbonyl, and alkylthio, A is N or C—H, B is N, C—H, C—(SO 2 —R 4 ), or C—CO—R 4 , D is N, C—H, C—(SO 2 —R 4 ) or C—CO—R 4 , E is N or C—H, wherein only one of A, B or E may be N, and one of B or D is C—(SO 2 —R 4 ) or C—CO—R 4 , R 4 is a group having the formula: in which each R 5 , R 6 , R 7 and R 8 are independently selected from H and lower alkyl, wherein the lower alkyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO 2 , amino, acylamino, amido, carbonyl, and alkylthio; and additionally or alternatively R 6 and R 5 together form a 5- or 6-membered ring, or R 6 and R 7 together form a 3 to 6 membered ring; R 9 is independently selected from H and lower alkyl, wherein the lower alkyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO 2 , amino, acylamino, amido, carbonyl, and alkylthio; alternatively R 8 and R 9 together with the nitrogen to which they are attached form a 5- or 6-membered ring; n is 1 to 4; and m is 1 to 6.