brefeldin A | 1212753-20-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: brefeldin A
• 英文别名: Brefeldin A (BFA)；(1R,2R,3E,7S,11E,15S)-2,15-dihydroxy-7-methyl-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-5-one
• CAS: 1212753-20-2
• 化学式: C₁₆H₂₄O₄
• 分子量: 280.364
• InChiKey: KQNZDYYTLMIZCT-KFKPYADVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  brefeldin A 在 Collins oxidation agent 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 21.0h， 生成 (2E,6S,10E,11aS,13S,14aR,)-7,8,9,11a,12,13,14,14a-octahydro-13-(2-methoxyethoxymethoxy)-6-methyl-6H-cyclopent--oxacyclotridecin-1,4-dione
  参考文献：
  名称：

  Marx, Karl-Heinz; Raddatz, Peter; Winterfeldt, Ekkehard, Liebigs Annalen der Chemie, 1984, # 3, p. 474 - 482

  摘要：

  DOI：

文献信息

• COMPOUNDS AND METHODS FOR TREATMENT AND PREVENTION OF FLAVIVIRUS INFECTION
  申请人：FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

  公开号：US20180015153A1

  公开（公告）日：2018-01-18

  The present invention concerns the use of compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering a compound or class of compound disclosed herein, such as a niclosamide compound, an emricasan compound, a cyclin-dependent kinase inhibitor, a proteasome inhibitor, or a combination of two or more of the foregoing, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections.

  本发明涉及化合物用于治疗或预防黄病毒感染，如寨卡病毒感染。该发明的方面包括通过给予本文所披露的化合物或化合物类别，如尼克洛酰胺化合物、恩米卡珊化合物、细胞周期依赖性激酶抑制剂、蛋白酶体抑制剂或前述两种或更多的组合，治疗或预防黄病毒感染，如寨卡病毒感染的方法；在体外或体内抑制黄病毒感染，如寨卡病毒感染的方法；制药组合；包装剂量配方；以及用于治疗或预防黄病毒感染，如寨卡病毒感染的工具包。
• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• Compounds and methods for treatment and prevention of Flavivirus infection
  申请人：FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

  公开号：US10940188B2

  公开（公告）日：2021-03-09

  The present invention concerns the use of compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering a compound or class of compound disclosed herein, such as a niclosamide compound, an emricasan compound, a cyclin-dependent kinase inhibitor, a proteasome inhibitor, or a combination of two or more of the foregoing, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections.

  本发明涉及使用化合物治疗或预防弗拉维病毒感染，如寨卡病毒感染。本发明的方面包括通过向有需要的受试者施用本文公开的化合物或化合物类别，如烟酰胺化合物、依木酰胺化合物、细胞周期蛋白依赖性激酶抑制剂、蛋白酶体抑制剂或上述两种或多种的组合，治疗或预防弗拉维病毒感染，如寨卡病毒感染的方法；抑制体外或体内细胞中黄病毒感染（如寨卡病毒感染）的方法；药物组合物；包装剂型；以及治疗或预防黄病毒感染（如寨卡病毒感染）的试剂盒。
• Biosynthesis of macrolide antibiotics. 6. Late steps in brefeldin A biosynthesis
  作者：Yoshikuni Yamamoto、Akira Hori、C. Richard Hutchinson

  DOI：10.1021/ja00294a045

  日期：1985.4
• CAPTURE COMPOUNDS, COLLECTIONS THEREOF AND METHODS FOR ANALYZING THE PROTEOME AND COMPLEX COMPOSITIONS
  申请人：caprotec bioanalytics GmbH

  公开号：EP1485707B1

  公开（公告）日：2009-01-14