((4R,5S)-1,5-dimethyl-2-oxo-4-phenylimidazolidin-3-yl)acetic acid | 184717-02-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: ((4R,5S)-1,5-dimethyl-2-oxo-4-phenylimidazolidin-3-yl)acetic acid
• 英文别名: 2-[(4S,5R)-3,4-dimethyl-2-oxo-5-phenylimidazolidin-1-yl]acetic acid
• CAS: 184717-02-0
• 化学式: C₁₃H₁₆N₂O₃
• 分子量: 248.282
• InChiKey: FAHAKOPHASRNIV-CABZTGNLSA-N

物化性质

• 沸点：
  447.9±45.0 °C(Predicted)
• 密度：
  1.218±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  60.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ((4R,5S)-1,5-dimethyl-2-oxo-4-phenylimidazolidin-3-yl)acetic acid 在 草酰氯 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.25h， 生成 (4S,5R)-1-[(2R,3R)-1-benzyl-2-[(S)-[tert-butyl(dimethyl)silyl]oxy-phenylmethyl]-4-oxoazetidin-3-yl]-3,4-dimethyl-5-phenylimidazolidin-2-one
  参考文献：
  名称：

  A Study on the Asymmetric Synthesis of β-Lactams through Double Stereodifferentiating Cycloaddition Reactions

  摘要：

  The cycloaddition reaction of chiral aminoketenes, generated from their corresponding acid chlorides and triethylamine, with chiral imines is evaluated as the most direct approach for the construction of cis-beta-lactams with the absolute stereochemistry at the C-3 and C-4 positions being controlled by the ketene partner, independently of the absolute stereochemistry of the imine component.

  DOI：

  10.1021/jo9612180
• 作为产物：
  描述：

  (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 、 溴乙酸甲酯 在 sodium hydroxide 、 sodium hydride 作用下， 生成 ((4R,5S)-1,5-dimethyl-2-oxo-4-phenylimidazolidin-3-yl)acetic acid
  参考文献：
  名称：

  A Study on the Asymmetric Synthesis of β-Lactams through Double Stereodifferentiating Cycloaddition Reactions

  摘要：

  The cycloaddition reaction of chiral aminoketenes, generated from their corresponding acid chlorides and triethylamine, with chiral imines is evaluated as the most direct approach for the construction of cis-beta-lactams with the absolute stereochemistry at the C-3 and C-4 positions being controlled by the ketene partner, independently of the absolute stereochemistry of the imine component.

  DOI：

  10.1021/jo9612180

文献信息

• A Study on the Asymmetric Synthesis of β-Lactams through Double Stereodifferentiating Cycloaddition Reactions
  作者：Claudio Palomo、Jesús M. Aizpurua、Antonia Mielgo、Anthony Linden

  DOI：10.1021/jo9612180

  日期：1996.1.1

  The cycloaddition reaction of chiral aminoketenes, generated from their corresponding acid chlorides and triethylamine, with chiral imines is evaluated as the most direct approach for the construction of cis-beta-lactams with the absolute stereochemistry at the C-3 and C-4 positions being controlled by the ketene partner, independently of the absolute stereochemistry of the imine component.