1-[[(3'aR,4S,6'R,6'aR)-2,2,2',2'-tetramethylspiro[1,3-dioxolane-4,4'-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole]-6'-yl]methoxy]-3-[(4-methoxyphenyl)methyl]urea | 154014-01-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[[(3'aR,4S,6'R,6'aR)-2,2,2',2'-tetramethylspiro[1,3-dioxolane-4,4'-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole]-6'-yl]methoxy]-3-[(4-methoxyphenyl)methyl]urea
• CAS: 154014-01-4
• 化学式: C₂₁H₃₀N₂O₈
• 分子量: 438.478
• InChiKey: DRDUOJCJFZAXSO-LHUKNYEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1-[[(3'aR,4S,6'R,6'aR)-2,2,2',2'-tetramethylspiro[1,3-dioxolane-4,4'-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole]-6'-yl]methoxy]-3-[(4-methoxyphenyl)methyl]urea 在 三氟甲磺酸三甲基硅酯 作用下， 以 乙腈 为溶剂， 以97%的产率得到
  参考文献：
  名称：

  Natural products as pesticides: Two examples of stereoselective synthesis

  摘要：

  The strategy and synthetic efforts leading to efficient stereoselective syntheses of thiangazole, a tris-thiazolinyl-oxazole metabolite isolated from Poly-angium spp., and of hydantocidin, a spironucleoside metabolite isolated from Streptomyces hygroscopicus, are discussed.

  DOI：

  10.1002/(sici)1096-9063(199601)46:1<37::aid-ps339>3.0.co;2-k
• 作为产物：
  描述：

  1,2:3,4-di-O-isopropylidene-β-D-psicofuranose 在 三氟甲磺酸三甲基硅酯 、 三苯基膦 、 肼 、 偶氮二甲酸二乙酯 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 2.0h， 生成 1-[[(3'aR,4S,6'R,6'aR)-2,2,2',2'-tetramethylspiro[1,3-dioxolane-4,4'-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole]-6'-yl]methoxy]-3-[(4-methoxyphenyl)methyl]urea
  参考文献：
  名称：

  Natural products as pesticides: Two examples of stereoselective synthesis

  摘要：

  The strategy and synthetic efforts leading to efficient stereoselective syntheses of thiangazole, a tris-thiazolinyl-oxazole metabolite isolated from Poly-angium spp., and of hydantocidin, a spironucleoside metabolite isolated from Streptomyces hygroscopicus, are discussed.

  DOI：

  10.1002/(sici)1096-9063(199601)46:1<37::aid-ps339>3.0.co;2-k

文献信息

• Natural products as pesticides: Two examples of stereoselective synthesis
  作者：Thomas Früh、Philippe Chemla、Jürg Ehrler、Saleem Farooq

  DOI：10.1002/(sici)1096-9063(199601)46:1<37::aid-ps339>3.0.co;2-k

  日期：1996.1

  The strategy and synthetic efforts leading to efficient stereoselective syntheses of thiangazole, a tris-thiazolinyl-oxazole metabolite isolated from Poly-angium spp., and of hydantocidin, a spironucleoside metabolite isolated from Streptomyces hygroscopicus, are discussed.