4-chloro-2-fluoro-5-(1-methylethoxy)phenylhydrazine | 91167-64-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-2-fluoro-5-(1-methylethoxy)phenylhydrazine
• 英文别名: 2-fluoro-4-chloro-5-isopropoxy-phenylhydrazine；4-Chloro-2-fluoro-5-isopropoxyphenylhydrazine；(4-Chloro-2-fluoro-5-propan-2-yloxyphenyl)hydrazine
• CAS: 91167-64-5
• 化学式: C₉H₁₂ClFN₂O
• 分子量: 218.658
• InChiKey: VTVSBTRQHFFZAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  47.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-chloro-2-fluoro-5-(1-methylethoxy)phenylhydrazine 在 三氯氧磷 作用下， 生成 3-chloro-2-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4,5,6,7-tetrahydro-2H-indazole
  参考文献：
  名称：

  Ando, Iwao; Ohtsuka, Toshikazu; Miki, Nobuo, Agricultural and Biological Chemistry, 1989, vol. 53, # 7, p. 2001 - 2004

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯-4-氟-5-硝基苯酚 在 氢气 、 tin(ll) chloride 、 sodium nitrite 作用下， 生成 4-chloro-2-fluoro-5-(1-methylethoxy)phenylhydrazine
  参考文献：
  名称：

  Ando, Iwao; Ohtsuka, Toshikazu; Miki, Nobuo, Agricultural and Biological Chemistry, 1989, vol. 53, # 7, p. 2001 - 2004

  摘要：

  DOI：

文献信息

• Pyridazin-3-one derivatives, their use, and intermediates for their
  申请人：Sumitomo Chemical Company Limited

  公开号：US06090753A1

  公开（公告）日：2000-07-18

  Novel pyridazin-3-one derivatives of formula [1] are provided, which are useful as active ingredients of herbicides, wherein R.sup.1 is haloalkyl; R.sup.2 and R.sup.3 are the same or different and are hydrogen, alkyl, haloalkyl, or alkoxyalkyl; and Q is [Q-1], [Q-2], [Q-3], [Q-4], or [Q-5]. Also provided are their use and intermediates for their production.

  提供了式[1]的新型吡啶并嗪-3-酮衍生物，其作为除草剂的活性成分，其中R.sup.1是卤代烷基；R.sup.2和R.sup.3相同或不同，可以是氢、烷基、卤代烷基或烷氧基烷基；Q是[Q-1]、[Q-2]、[Q-3]、[Q-4]或[Q-5]。还提供了它们的用途和生产中间体。
• Production of pyridazine herbicides
  申请人：Sumitomo Chemical Company, Limited

  公开号：US06156891A1

  公开（公告）日：2000-12-05

  Carboxylic acids of formula (1): ##STR1## wherein R.sup.2 and R.sup.3 are independently hydrogen or C.sub.1 -C.sub.3 alkyl, and Q is optionally substituted phenyl, can be easily converted by ring closing into pyridazin-3-one derivatives of formula (7): ##STR2## The carboxylic acids of formula (1) can be produced by reacting hydrazone compounds of formula (5): ##STR3## wherein R.sup.3 and Q are as defined above, with malonic acid derivatives of formula (6): R.sup.2 CH(COOH).sub.2 wherein R.sup.2 is as defined above in the presence of a base.

  公式（1）的羧酸：其中R.sup.2和R.sup.3分别独立表示氢或C.sub.1-C.sub.3烷基，Q是可选择取代的苯基，可以通过环闭合轻松转化为公式（7）的吡啶并[3,2-b]吡嗪-3-酮衍生物：##STR2## 公式（1）的羧酸可以通过将公式（5）的腙化合物与公式（6）的丙二酸衍生物在碱存在下反应制备，其中R.sup.3和Q如上定义，R.sup.2 CH(COOH).sub.2中的R.sup.2如上定义。
• Production pyridazine herbicides
  申请人：Sumitomo Chemical Company, Limited

  公开号：US06204380B1

  公开（公告）日：2001-03-20

  Carboxylic acid ester derivatives of formula (1): wherein R is C1-C6 alkyl, R2 and R3 are independently hydrogen or C1-C3 alkyl, and Q is optionally substituted phenyl, can be easily converted by ring closing into pyridazin-3-one derivatives of formula (7): The carboxylic acids of formula (1) can be produced by reacting hydrazone compounds of formula (5): wherein R3 and Q are as defined above, with malonic acid monoester derivatives of formula (6): wherein R and R2 are as defined above, in the presence of a base.

  公式（1）的羧酸酯衍生物如下：其中R为C1-C6烷基，R2和R3分别为氢或C1-C3烷基，Q为可选择取代的苯基，可以通过环闭合转化为公式（7）的吡啶并[1,2,4]三嗪衍生物：公式（1）的羧酸可通过将公式（5）的腙化合物与公式（6）的丙二酸单酯衍生物在碱存在下反应而制备：其中R3和Q如上定义，R和R2如上定义。
• Herbicidal fluoropropyl compounds
  申请人：FMC Corporation

  公开号：US04906284A1

  公开（公告）日：1990-03-06

  Herbicidal compound of the formula ##STR1## whose Difluoromethyl Analog or Methyl Analog is a herbicide (the Difluoromethyl Analog being identical except that it has a --CHF.sub.2 group instead of the --CH.sub.2 CH.sub.2 CH.sub.2 F group of said compound and the Methyl Analog being identical except that it has a --CH.sub.3 group instead of the --CH.sub.2 CH.sub.2 CH.sub.2 F group of said compound), Ar being an aryl radical.

  该化合物的除草剂化合物的分子式为##STR1##，其二氟甲基类似物或甲基类似物是一个除草剂（其中二氟甲基类似物与该化合物的--CH.sub.2 CH.sub.2 CH.sub.2 F基团相同，只是它有一个--CHF.sub.2基团，而甲基类似物与该化合物的--CH.sub.2 CH.sub.2 CH.sub.2 F基团相同，只是它有一个--CH.sub.3基团），其中Ar为芳基基团。
• Pyridazin-3-one derivatives, their use, and intermediates for their production
  申请人：Sumitomo Chemical Company, Limited

  公开号：US06348628B1

  公开（公告）日：2002-02-19

  Novel hydrazones of formula [2] having the following structural formula are provided, which are useful intermediates to form active ingredients of herbicides, wherein R3 is hydrogen, alkyl, haloalkyl, or alkoxy alkyl; and Q is [Q-1], [Q-2], [Q-3], [Q-4] or [Q-5] as defined herein.

  提供具有以下结构式的新型肼酮[2]，其中R3为氢、烷基、卤代烷基或烷氧基烷基；Q为[Q-1]、[Q-2]、[Q-3]、[Q-4]或[Q-5]，用于形成除草剂的活性成分的中间体。