3-cyclopropyl-5-nitroaniline | 1239596-35-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-cyclopropyl-5-nitroaniline
• CAS: 1239596-35-0
• 化学式: C₉H₁₀N₂O₂
• 分子量: 178.191
• InChiKey: AGNVJMHCTBMXEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-cyclopropyl-5-nitroaniline 在 盐酸 、 氢溴酸 、 sodium cyanoborohydride 、 溶剂黄146 、 sodium nitrite 作用下， 以 1,4-二氧六环 、 甲醇 、 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 52.5h， 生成 ((2R,3R,4R,5S)-1-{[4-({[3-cyclopropyl-5-(morpholin-4-yl)phenyl]amino}methyl)phenyl]methyl}-2-(hydroxymethyl)piperidine 3,4,5-triol)
  参考文献：
  名称：

  [EN] DEOXYNOJIRIMYCIN DERIVATIVES AS GLUCOSIDASE INHIBITORS
  [FR] DÉRIVÉS DE DÉSOXYNOJIRIMYCINE EN TANT QU'INHIBITEURS DE GLUCOSIDASE

  摘要：

  本申请提供了新颖的亚胺糖以及它们作为葡萄糖苷酶抑制剂的用途。本发明人发现某些脱氧诺吉霉素衍生物可能有效地抑制葡萄糖苷酶。特别是，这些脱氧诺吉霉素衍生物可能对治疗需要抑制葡萄糖苷酶的疾病或病况有用。

  公开号：

  WO2022011211A1
• 作为产物：
  描述：

  1-Cyclopropyl 3,5-dinitrobenzene 在 硫化氢铵 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 生成 3-cyclopropyl-5-nitroaniline
  参考文献：
  名称：

  PROTEIN KINASE C INHIBITORS AND USES THEREOF

  摘要：

  这项披露涉及作为蛋白激酶C（PKC）抑制剂有用的化合物，因此可用于治疗通过PKC活性介导或维持的各种疾病和疾病。该披露还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和疾病的方法，制备这些化合物的过程以及在这些过程中有用的中间体。

  公开号：

  US20100204208A1

文献信息

• TETRAZOLONES AS PROTEIN KINASE C INHIBITORS AND USES THEREOF
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP2507227B1

  公开（公告）日：2014-10-08
• Protein Kinase C Inhibitors and Uses Thereof
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20170152246A1

  公开（公告）日：2017-06-01

  This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
• US9732070B2
  申请人：——

  公开号：US9732070B2

  公开（公告）日：2017-08-15
• [EN] PROTEIN KINASE C INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE LA PROTÉINE KINASE C ET LEURS UTILISATIONS
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2011068898A1

  公开（公告）日：2011-06-09

  This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseThis disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.ases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
• PROTEIN KINASE C INHIBITORS AND USES THEREOF
  申请人：Singh Rajinder

  公开号：US20110130415A1

  公开（公告）日：2011-06-02

  This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

  这项披露涉及作为蛋白激酶C（PKC）抑制剂有用的化合物，因此对于治疗通过PKC活性介导或维持的各种疾病和疾病非常有用。这项披露还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和疾病的方法，制备这些化合物的过程以及在这些过程中有用的中间体。