(E)-N-methyl-N-2-butenyl-1-naphthalenemethanamine | 98978-14-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (E)-N-methyl-N-2-butenyl-1-naphthalenemethanamine
• 英文别名: (E)-N-methyl-N-(naphthalen-1-ylmethyl)but-2-en-1-amine
• CAS: 98978-14-4
• 化学式: C₁₆H₁₉N
• 分子量: 225.334
• InChiKey: UUJUDDDAMMVOSB-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (氯甲基)萘 在 sodium carbonate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 (E)-N-methyl-N-2-butenyl-1-naphthalenemethanamine
  参考文献：
  名称：

  Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics

  摘要：

  Naftifine (1) is the first representative of the new antifungal allylamine derivatives. Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals. A tertiary allylamine function seems to be a prerequisite for activity against fungi. By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations. Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.

  DOI：

  10.1021/jm00151a019

文献信息

• Direct use of allylic alcohols and allylic amines in palladium-catalyzed allylic amination
  作者：Jiangyan Jing、Xiaohong Huo、Jiefeng Shen、Jingke Fu、Qinghua Meng、Wanbin Zhang

  DOI：10.1039/c7cc01069a

  日期：——

  Allylic alcohols and allylic amines were directly utilized in a Pd-catalyzed hydrogen-bond-activated allylic amination under mild reaction conditions in the absence of any additives. The cooperative action of a Pd-catalyst and a hydrogen-bonding solvent is most likely responsible for its high reactivity. The catalytic system is compatible with a variety of functional groups and can be used to prepare

  在没有任何添加剂的情况下，在温和的反应条件下，将烯丙醇和烯丙基胺直接用于钯催化的氢键活化的烯丙基胺化反应中。Pd催化剂和氢键溶剂的协同作用很可能是其高反应活性的原因。该催化体系与多种官能团相容，可用于以良好或优异的收率制备各种线性烯丙基胺。此外，该方法可以轻松地以克为单位，用于两种药物的肉桂醛和萘替芬的一步合成。
• Antibacterial Agents
  申请人：Wang Guijun

  公开号：US20090048240A1

  公开（公告）日：2009-02-19

  This invention provides compositions which are 1,3-oxazinan-2-one compounds of formulae (I) and (II), and oxazolidinone compounds of formula (III): wherein R is a hydrocarbyl group, a heterocyclic group, a hydrocarbyl group having at least one substituent, or a heterocyclic group having at least one hydrocarbyl substituent, wherein the substituent on the hydrocarbyl group or heterocyclic group is selected from the group consisting of a heterocyclic group, an azo group, a cyano group, a nitro group, a fluoro group, a chloro group, a bromo group, an alkoxy group having up to 15 carbon atoms, and a hydrocarbyl group having up to 15 carbon atoms; and R′ and R″ are each independently hydrogen, an alkyl group, an aryl group, a methylaryl group, a carbonyl group, a hydrocarbylamido group, a sulfonyl group, a sulfonamoyl group, a heterocyclic group, a heterocyclic group having at least one substituent, or an aryl group or methylaryl group having at least one substituent, where the substituent on the heterocyclic group, aryl group, or methylaryl group is selected from the group consisting of a heterocyclic group, an azo group, a cyano group, a nitro group, a fluoro group, a chloro group, a bromo group, an alkoxy group having up to 15 carbon atoms, and a hydrocarbyl group having up to 15 carbon atoms. For the oxazolidinone compound of formula (HI), there is a proviso that when one of R′ or R″ is a (3-fluoro)-(4-morpholinyl)-phenyl group, the other of R′ or R″ is not an acetamido group.

  本发明提供了式(I)和(II)的1,3-噁唑烷-2-酮化合物和式(III)的噁唑烷酮化合物，其中R是一个烃基团、一个杂环基团、至少有一个取代基的烃基团或至少有一个烃基取代基的杂环基团，其中烃基团或杂环基团上的取代基被选择为由杂环基团、偶氮基、氰基、硝基、氟基、氯基、溴基、具有多达15个碳原子的烷氧基和具有多达15个碳原子的烃基组成的群。R'和R"各自独立地是氢、烷基、芳基、甲基芳基、羰基、烃基酰胺基、磺酰基、磺酰胺基、杂环基、至少有一个取代基的杂环基、或至少有一个取代基的芳基或甲基芳基，其中杂环基、芳基或甲基芳基上的取代基被选择为由杂环基团、偶氮基、氰基、硝基、氟基、氯基、溴基、具有多达15个碳原子的烷氧基和具有多达15个碳原子的烃基组成的群。对于式(III)的噁唑烷酮化合物，有一个限定条件，即当R'或R"中的一个是(3-氟)-(4-吗啉基)-苯基时，另一个不能是乙酰胺基。
• US7288678B2
  申请人：——

  公开号：US7288678B2

  公开（公告）日：2007-10-30
• US7700590B2
  申请人：——

  公开号：US7700590B2

  公开（公告）日：2010-04-20
• Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics
  作者：Anton Stuetz、Apostolos Georgopoulos、Waltraud Granitzer、Gabor Petranyi、Daniel Berney

  DOI：10.1021/jm00151a019

  日期：1986.1

  Naftifine (1) is the first representative of the new antifungal allylamine derivatives. Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals. A tertiary allylamine function seems to be a prerequisite for activity against fungi. By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations. Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.