N-methyl-3-methyl-3-[(methylamino)-3-oxopropyl]aminopropanamide | 888011-54-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-methyl-3-methyl-3-[(methylamino)-3-oxopropyl]aminopropanamide
• 英文别名: N-methyl-3-[methyl-[3-(methylamino)-3-oxopropyl]amino]propanamide
• CAS: 888011-54-9
• 化学式: C₉H₁₉N₃O₂
• 分子量: 201.269
• InChiKey: DVCJZHNZVZMKPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  61.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-methyl-3-methyl-3-[(methylamino)-3-oxopropyl]aminopropanamide 在 lithium aluminium tetrahydride 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 12.0h， 生成 methyl 6,10,14-trimethyl-3-oxo-2-oxa-6,10,14-triazaheptadecan-17-oate
  参考文献：
  名称：

  A new stepwise synthesis of a family of propylamines derived from diatom silaffins and their activity in silicification

  摘要：

  介绍了一种逐步合成含有硅藻生物提取物中发现的 N-甲基丙胺片段的丙胺的新方法，并描述了它们在硅酸缩合中的活性。

  DOI：

  10.1039/b515967a
• 作为产物：
  描述：

  N,N-二-(beta-羰基乙氧基乙基)甲胺 、 甲胺 以 乙醇 为溶剂， 以99%的产率得到N-methyl-3-methyl-3-[(methylamino)-3-oxopropyl]aminopropanamide
  参考文献：
  名称：

  A new stepwise synthesis of a family of propylamines derived from diatom silaffins and their activity in silicification

  摘要：

  介绍了一种逐步合成含有硅藻生物提取物中发现的 N-甲基丙胺片段的丙胺的新方法，并描述了它们在硅酸缩合中的活性。

  DOI：

  10.1039/b515967a

文献信息

• AMINE-CONTAINING LIPIDS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20160009657A1

  公开（公告）日：2016-01-14

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
• NITRIC OXIDE-RELEASING POLYAMINOGLYCOSIDES AS BIODEGRADABLE ANTIBACTERIAL SCAFFOLDS AND METHODS PERTAINING THERETO
  申请人：THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

  公开号：US20200030362A1

  公开（公告）日：2020-01-30

  Provided herein are hyperbranched polyaminoglycosides, where in some embodiments, the hyperbranched polyaminoglycosides are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of hyperbranched polyaminoglycosides. In some embodiments, the covalently modified hyperbranched polyaminoglycosides may be tailored to release nitric oxide in a controlled manner and are useful for eradication of both gram positive and gram negative bacteria as well as other microbes.
• A new stepwise synthesis of a family of propylamines derived from diatom silaffins and their activity in silicification
  作者：Vadim V. Annenkov、Siddharth V. Patwardhan、David Belton、Elena N. Danilovtseva、Carole C. Perry

  DOI：10.1039/b515967a

  日期：——

  A new method for the stepwise synthesis of propylamines containing fragments of N-methyl propylamine as found in diatom bioextracts is presented and their activity in silicic acid condensation is described.

  介绍了一种逐步合成含有硅藻生物提取物中发现的 N-甲基丙胺片段的丙胺的新方法，并描述了它们在硅酸缩合中的活性。