1-Benzyl-4-oxido-1-aza-4-azoniaspiro[4.5]dec-3-en-2-one | 936240-33-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Benzyl-4-oxido-1-aza-4-azoniaspiro[4.5]dec-3-en-2-one
• CAS: 936240-33-4
• 化学式: C₁₅H₁₈N₂O₂
• 分子量: 258.32
• InChiKey: XLEYFCZCUWZYQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  49.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Benzyl-4-oxido-1-aza-4-azoniaspiro[4.5]dec-3-en-2-one 在 N,N-二异丙基乙胺 、 三氯氧磷 作用下， 以 甲苯 为溶剂， 反应 16.0h， 以51%的产率得到
  参考文献：
  名称：

  A Novel Method for the Preparation of 4-Arylimidazolones

  摘要：

  A series of 4-arylimidazolones have been accessed via late-stage, palladium-mediated arylation of acetone- and cyclohexanone-derived 4-chloroimidazolones. The 4-chloroimidazolones were prepared via a novel rearrangement of the corresponding imidazolone N-oxides. This communication serves as an expansion of chemistry originally developed for our glucagon receptor antagonist program.

  DOI：

  10.1021/ol401165e
• 作为产物：
  描述：

  在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 以2.08 g的产率得到1-Benzyl-4-oxido-1-aza-4-azoniaspiro[4.5]dec-3-en-2-one
  参考文献：
  名称：

  A Novel Method for the Preparation of 4-Arylimidazolones

  摘要：

  A series of 4-arylimidazolones have been accessed via late-stage, palladium-mediated arylation of acetone- and cyclohexanone-derived 4-chloroimidazolones. The 4-chloroimidazolones were prepared via a novel rearrangement of the corresponding imidazolone N-oxides. This communication serves as an expansion of chemistry originally developed for our glucagon receptor antagonist program.

  DOI：

  10.1021/ol401165e

文献信息

• Formal Olefination and Acylaziridination of Imidazolones
  作者：Xing Dai、Michael W. Miller、Andrew W. Stamford

  DOI：10.1021/ol1007923

  日期：2010.6.18

  The first formal olefination and acylaziridination of imidazolones were obtained by cycloaddition of cyclic nitrones with alkenes and alkynes, respectively.
• Versatile Spirocyclic Glycine‐Based Nitrones and Their Highly Stereoselective 1,3‐Dipolar Cycloaddition
  作者：Shangli Cheng、Huimin Wu、Xianmin Hu

  DOI：10.1080/00397910601033781

  日期：2007.2.1

  A convenient and efficient method for the synthesis of novel spirocyclic nitrones prepared from glycine derivatives is reported. The 1,3-cycloaddition reactions of the nitrones with alkenes lead to novel isoxazolidines in high yields and with excellent regio- and stereoselectivity.