rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyridin-3-yl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide | 672949-12-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyridin-3-yl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide
• 英文别名: N-[(4-chlorophenyl)methyl]-2-[[(2-hydroxy-2-pyridin-3-ylethyl)-methylamino]methyl]-7-methyl-4-oxothieno[2,3-b]pyridine-5-carboxamide
• CAS: 672949-12-1；672949-14-3
• 化学式: C₂₅H₂₅ClN₄O₃S
• 分子量: 497.018
• InChiKey: KWVHNLFCPVDMNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  PNU-243672 在 氯甲酸乙酯 、 N,N-二异丙基乙胺 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 生成 rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyridin-3-yl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide
  参考文献：
  名称：

  2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

  摘要：

  A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.102

文献信息

• [EN] HETEROARYL-ETHANOLAMINE DERIVATIVES AS ANTIVIRAL AGENTS<br/>[FR] DERIVES D'HETEROARYL-ETHANOLAMINE EN TANT QU'AGENTS ANTIVIRAUX
  申请人：UPJOHN CO

  公开号：WO2004022567A1

  公开（公告）日：2004-03-18

  The present invention provides a compound of formula (I), which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.

  本发明提供了一种化合物(I)的公式，其作为抗病毒剂特别是抗疱疹病毒家族的药剂。
• Heteroaryl-ethanolamine derivatives as antiviral agents
  申请人：——

  公开号：US20040110787A1

  公开（公告）日：2004-06-10

  The present invention provides a compound of formula as described herein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.

  本发明提供了一种如下式的化合物，其作为抗病毒剂具有用途，特别是作为对抗疱疹家族病毒的剂：