[2-[2-[1-(1,4,7,10,13-Pentaoxacyclopentadec-2-ylmethoxy)ethoxy]ethoxy]phenyl]methyl 2-chloro-2-phenylacetate | 1250366-65-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-[2-[1-(1,4,7,10,13-Pentaoxacyclopentadec-2-ylmethoxy)ethoxy]ethoxy]phenyl]methyl 2-chloro-2-phenylacetate
• 英文别名: [2-[2-[1-(1,4,7,10,13-pentaoxacyclopentadec-2-ylmethoxy)ethoxy]ethoxy]phenyl]methyl 2-chloro-2-phenylacetate
• CAS: 1250366-65-4
• 化学式: C₃₀H₄₁ClO₁₀
• 分子量: 597.103
• InChiKey: YLUDJRCYPJRBMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  41
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  100
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  [2-[2-[1-(1,4,7,10,13-Pentaoxacyclopentadec-2-ylmethoxy)ethoxy]ethoxy]phenyl]methyl 2-chloro-2-phenylacetate 、 sodium methacrylate 在 1,2,3,4-四氢萘 、 (η5-indenyl)ruthenium(bis(triphenylphosphine))chloride 、 甲基丙烯酰氧乙基三甲基氯化铵 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Template-Assisted Selective Radical Addition toward Sequence-Regulated Polymerization: Lariat Capture of Target Monomer by Template Initiator

  摘要：

  Surprisingly high monomer selectivity was demonstrated in competitive radical addition with two kinds of methacrylates carrying sodium and ammonium cation. Crucial is size-specific recognition by a lariat crown ether embedded close to the reactive halide in a designer template initiator. Especially, a combination with an active ruthenium catalyst led to outstanding selectivity at low temperature. This template system will open the way to unprecedented sequence-regulated polymerization.

  DOI：

  10.1021/ja1070575
• 作为产物：
  描述：

  2-[2-(1-chloroethoxy)ethoxy]benzyl 2-chloro-2-phenylacetate 、 2-羟甲基-15-冠-5 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以57%的产率得到[2-[2-[1-(1,4,7,10,13-Pentaoxacyclopentadec-2-ylmethoxy)ethoxy]ethoxy]phenyl]methyl 2-chloro-2-phenylacetate
  参考文献：
  名称：

  Template-Assisted Selective Radical Addition toward Sequence-Regulated Polymerization: Lariat Capture of Target Monomer by Template Initiator

  摘要：

  Surprisingly high monomer selectivity was demonstrated in competitive radical addition with two kinds of methacrylates carrying sodium and ammonium cation. Crucial is size-specific recognition by a lariat crown ether embedded close to the reactive halide in a designer template initiator. Especially, a combination with an active ruthenium catalyst led to outstanding selectivity at low temperature. This template system will open the way to unprecedented sequence-regulated polymerization.

  DOI：

  10.1021/ja1070575

文献信息

• Template-Assisted Selective Radical Addition toward Sequence-Regulated Polymerization: Lariat Capture of Target Monomer by Template Initiator
  作者：Shohei Ida、Makoto Ouchi、Mitsuo Sawamoto

  DOI：10.1021/ja1070575

  日期：2010.10.27

  Surprisingly high monomer selectivity was demonstrated in competitive radical addition with two kinds of methacrylates carrying sodium and ammonium cation. Crucial is size-specific recognition by a lariat crown ether embedded close to the reactive halide in a designer template initiator. Especially, a combination with an active ruthenium catalyst led to outstanding selectivity at low temperature. This template system will open the way to unprecedented sequence-regulated polymerization.