3-methyl 5-(2-bromoethyl) (+/-)-1-ethoxymethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate 、
sodium 4-methylbenzenesulfinate 在
sodium hydroxide 、
苄基三乙基氯化铵 作用下,
以
N-甲基乙酰胺 、 (2S)-N-methyl-1-phenylpropan-2-amine hydrate 为溶剂,
生成 3-methyl 5-{3-[4-(2-methoxyphenyl)-1-piperazinyl]-propyl} (+)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate