L-Rhamnose-hydrazon | 815-98-5

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 炔丙基型1，3-偶极有机化合物
• 英文名称: L-Rhamnose-hydrazon
• 英文别名: (2S,3S,4S,5S)-1-hydrazinylidenehexane-2,3,4,5-tetrol
• CAS: 815-98-5
• 化学式: C₆H₁₄N₂O₄
• 分子量: 178.188
• InChiKey: PFLWIKNSIJUAMW-BXKVDMCESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  119
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  L-Rhamnose-hydrazon 、 乙酰丙酮 以 水 为溶剂， 反应 2.0h， 生成 、 、 、
  参考文献：
  名称：

  Heterocyclic derivatives of sugars: an NMR study of the formation of 1-glycosyl-3,5-dimethyl-1 H-pyrazoles from hydrazones

  摘要：

  Hydrazones were prepared by treatment of monosaccharides and disaccharides with hydrazine hydrate and converted in high yield to mixtures of 1-glycosyl-3,5-dimethyl-1 H-pyrazoles by reaction with pentan-2,4-dione (acetylacetone). The isomeric products were separated by HPLC and characterized by NMR spectroscopy. This represents a new approach to the introduction of a heteroaromatic label into sugars under nonacidic and nonreducing conditions, and it is a process likely to be especially useful for glycan hydrazones obtained from glycoproteins by hydrazinolysis or beta elimination in the presence of hydrazine. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0008-6215(97)00007-4
• 作为产物：
  描述：

  L-rhamnose 在 一水合肼 作用下， 以 水 为溶剂， 生成 L-Rhamnose-hydrazon
  参考文献：
  名称：

  Heterocyclic derivatives of sugars: an NMR study of the formation of 1-glycosyl-3,5-dimethyl-1 H-pyrazoles from hydrazones

  摘要：

  Hydrazones were prepared by treatment of monosaccharides and disaccharides with hydrazine hydrate and converted in high yield to mixtures of 1-glycosyl-3,5-dimethyl-1 H-pyrazoles by reaction with pentan-2,4-dione (acetylacetone). The isomeric products were separated by HPLC and characterized by NMR spectroscopy. This represents a new approach to the introduction of a heteroaromatic label into sugars under nonacidic and nonreducing conditions, and it is a process likely to be especially useful for glycan hydrazones obtained from glycoproteins by hydrazinolysis or beta elimination in the presence of hydrazine. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0008-6215(97)00007-4

文献信息

• Stroh,H.-H. et al., Chemische Berichte, 1965, vol. 98, p. 1404 - 1410
  作者：Stroh,H.-H. et al.

  DOI：——

  日期：——