N-phenyl-4-(N-phenylsulfamoyl)benzamide | 26737-96-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-4-(N-phenylsulfamoyl)benzamide
• 英文别名: 4-phenylsulfamoyl-benzoic acid anilide；4-Phenylsulfamoyl-benzoesaeure-anilid；N-phenyl-4-(phenylsulfamoyl)benzamide
• CAS: 26737-96-2
• 化学式: C₁₉H₁₆N₂O₃S
• 分子量: 352.414
• InChiKey: UCOSOSLDIOQPPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  五氯化磷 、 N-phenyl-4-(N-phenylsulfamoyl)benzamide 、 苯 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  v.Braun; Rudolph, Chemische Berichte, 1941, vol. 74, p. 264,268

  摘要：

  DOI：
• 作为产物：
  描述：

  4-苯氨磺酰基苯甲酸 在 4-二甲氨基吡啶 、 三乙胺 、 N,N'-二异丙基碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 8.0h， 生成 N-phenyl-4-(N-phenylsulfamoyl)benzamide
  参考文献：
  名称：

  METHODS OF INHIBITING BACTERIAL VIRULENCE AND COMPOUNDS RELATING THERETO

  摘要：

  公开号：

  EP2219635B1

文献信息

• Methods of Inhibiting Bacterial Virulence and Compounds Relating Thereto
  申请人：Sperandio Vanessa

  公开号：US20100048573A1

  公开（公告）日：2010-02-25

  The present invention relates to compounds and methods for the treatment of bacterial infections. Because their mechanism of action does not involve killing of bacteria or inhibiting their growth, the potential for these compounds to induce drug resistance in bacteria is minimized. Through inhibiting bacterial virulence, the present invention provides a novel means of treating bacterial infections.

  本发明涉及化合物和方法，用于治疗细菌感染。由于它们的作用机制不涉及杀死细菌或抑制它们的生长，这些化合物诱导细菌耐药性的潜力被最小化。通过抑制细菌的毒力，本发明提供了治疗细菌感染的新方法。
• An ‘inside-out’ approach to suramin analogues
  作者：Ross P. McGeary、Andrew J. Bennett、Quoc B. Tran、Johannes Prins、Benjamin P. Ross

  DOI：10.1016/j.tet.2009.03.033

  日期：2009.5

  An approach to the synthesis of suramin analogues has been realised, which avoids synthetic problems associated with conventional routes. The use of isobutyl ester protecting groups for sulfonic acids was crucial to the success of the strategy, because these were able to be cleanly deprotected with sodium iodide, yielding the sodium salts of the corresponding sulfonic acids. (C) 2009 Elsevier Ltd. All rights reserved.
• US8252841B2
  申请人：——

  公开号：US8252841B2

  公开（公告）日：2012-08-28
• [EN] METHODS OF INHIBITING BACTERIAL VIRULENCE AND COMPOUNDS RELATING THERETO<br/>[FR] PROCÉDÉS D'INHIBITION DE LA VIRULENCE BACTÉRIENNE ET COMPOSÉS S'Y RAPPORTANT
  申请人：UNIV TEXAS

  公开号：WO2009088549A2

  公开（公告）日：2009-07-16

  The present invention relates to compounds and methods for the treatment of bacterial infections. Because their mechanism of action does not involve killing of bacteria or inhibiting their growth, the potential for these compounds to induce drug resistance in bacteria is minimized. Through inhibiting bacterial virulence, the present invention provides a novel means of treating bacterial infections.