N-allyl-N-(3-methylbenzyl)aniline | 913169-23-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-allyl-N-(3-methylbenzyl)aniline
• 英文别名: N-[(3-methylphenyl)methyl]-N-prop-2-enylaniline
• CAS: 913169-23-0
• 化学式: C₁₇H₁₉N
• 分子量: 237.345
• InChiKey: WCRLHSARFCIKDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-allyl-N-(3-methylbenzyl)aniline 在 三氟化硼乙醚 作用下， 生成 2-allyl-N-(3-methylbenzyl)aniline
  参考文献：
  名称：

  顺式-4-羟基-2-芳基-2,3,4,5-四氢-1(1H)-苯并氮杂的立体选择性合成的连续氨基-克莱森重排/分子内1,3-偶极环加成/还原裂解方法

  摘要：

  描述了一种新的立体选择性合成 cis-2-aryl-4-hydroxy-2,3,4,5-tetrahydro-1-benzazepines 从 N-allylanilines 利用芳香氨基-克莱森重排和分子内 1,3-偶极环加成方法。该序列涉及相应 N-苄基苯胺的 N-烯丙基化，然后是氨基-克莱森重排，随后用原位 1,3-偶极环加成氧化得到异恶唑烷，最后还原裂解异恶唑烷 NO 键。

  DOI：

  10.1055/s-2006-949654
• 作为产物：
  描述：

  N-(3-甲基苄基)苯胺 、 3-溴丙烯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 N-allyl-N-(3-methylbenzyl)aniline
  参考文献：
  名称：

  顺式-4-羟基-2-芳基-2,3,4,5-四氢-1(1H)-苯并氮杂的立体选择性合成的连续氨基-克莱森重排/分子内1,3-偶极环加成/还原裂解方法

  摘要：

  描述了一种新的立体选择性合成 cis-2-aryl-4-hydroxy-2,3,4,5-tetrahydro-1-benzazepines 从 N-allylanilines 利用芳香氨基-克莱森重排和分子内 1,3-偶极环加成方法。该序列涉及相应 N-苄基苯胺的 N-烯丙基化，然后是氨基-克莱森重排，随后用原位 1,3-偶极环加成氧化得到异恶唑烷，最后还原裂解异恶唑烷 NO 键。

  DOI：

  10.1055/s-2006-949654

文献信息

• Polyphenylene ether based resin composition
  申请人：Ozeki Juro

  公开号：US20060241212A1

  公开（公告）日：2006-10-26

  An object of the present invention is to prevent, in blending an inorganic filler for the purpose of improving rigidity of a thermoplastic resin, deterioration in impact resistance and surface smoothness caused by the inorganic filler. The invention relates to a polyphenylene ether based resin composition containing (a) from 10 to 93% by weight of a polyphenylene ether based resin and optionally a styrene based resin, (b) from 2 to 20% by weight of a styrene based thermoplastic elastomer modified with an imidazolidinone compound, and (c) from 5 to 60% by weight of an inorganic filler that has been surface treated with a silane compound.

  本发明的目的是在为提高热塑性树脂刚性而混合无机填料时，防止无机填料引起的抗冲击性和表面平滑性的恶化。本发明涉及一种聚苯醚基树脂组合物，该组合物含有：(a) 10-93%（按重量计）的聚苯醚基树脂和可选的苯乙烯基树脂；(b) 2-20%（按重量计）的用咪唑烷酮化合物改性的苯乙烯基热塑性弹性体；(c) 5-60%（按重量计）的用硅烷化合物进行表面处理的无机填料。
• Synthesis, structural elucidation and in vitro antiparasitic activity against Trypanosoma cruzi and Leishmania chagasi parasites of novel tetrahydro-1-benzazepine derivatives
  作者：Sandra Gómez-Ayala、Julián A. Castrillón、Alirio Palma、Sandra M. Leal、Patricia Escobar、Alí Bahsas

  DOI：10.1016/j.bmc.2010.05.018

  日期：2010.7

  Forty six new 1,4-epoxy-2-exo-aryl-and cis-2-aryl-4-hydroxytetrahydro-1-benzazepine derivatives were synthesized and fully characterized. All compounds were tested in vitro against both Trypanosoma cruzi and Leishmania chagasi parasites and also for cytotoxicity using Vero and THP-1 mammalian cell lines. Many of the evaluated compounds showed remarkable activity against the epimastigote and intracellular amastigote forms of T. cruzi, with IC50 values comparable with that of control drug nifurtimox, a nitrofuran derivative currently used in the treatment of Chagas' disease. Other derivatives were found to have good activity against L. chagasi promastigotes, with low toxicity against the mammalian cells, but neither of them was active on intracellular amastigotes of L. chagasi infecting THP-1 macrophages. (C) 2010 Elsevier Ltd. All rights reserved.
• US8030374B2
  申请人：——

  公开号：US8030374B2

  公开（公告）日：2011-10-04