N-methyl-2-(propanoylamino)benzamide | 50547-48-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl-2-(propanoylamino)benzamide
• CAS: 50547-48-3
• 化学式: C₁₁H₁₄N₂O₂
• mdl: MFCD07552456
• 分子量: 206.244
• InChiKey: QFEVNYKIEUNBHZ-UHFFFAOYSA-N

物化性质

• 沸点：
  453.8±28.0 °C(Predicted)
• 密度：
  1.149±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-methyl-2-(propanoylamino)benzamide 以 formamide 为溶剂， 反应 0.17h， 生成 2-乙基-3-甲基喹唑啉-4(3h)酮
  参考文献：
  名称：

  Rapid synthesis of 2,3-disubstituted-quinazolin-4-ones enhanced by microwave-assisted decomposition of formamide

  摘要：

  An efficient methodology for the preparation of a series of 2,3-disubstituted-quinazolin-4(3H) -ones is described via a three step reaction from anthranilic acid. The obtained results also reveal that microwave-assisted rapid decomposition of formamide under controlled conditions of power, temperature and time is a very convenient source of ammonia for the synthesis of 2-substituted-quinazolin-4(3H)-ones and other rings. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.07.114
• 作为产物：
  描述：

  2-乙基-苯并[d][1,3]噁嗪-4-酮 、 甲胺 以 二氯甲烷 为溶剂， 生成 N-methyl-2-(propanoylamino)benzamide
  参考文献：
  名称：

  Rapid synthesis of 2,3-disubstituted-quinazolin-4-ones enhanced by microwave-assisted decomposition of formamide

  摘要：

  An efficient methodology for the preparation of a series of 2,3-disubstituted-quinazolin-4(3H) -ones is described via a three step reaction from anthranilic acid. The obtained results also reveal that microwave-assisted rapid decomposition of formamide under controlled conditions of power, temperature and time is a very convenient source of ammonia for the synthesis of 2-substituted-quinazolin-4(3H)-ones and other rings. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.07.114

文献信息

• Rapid synthesis of 2,3-disubstituted-quinazolin-4-ones enhanced by microwave-assisted decomposition of formamide
  作者：Ioannis K. Kostakis、Abdelhakim Elomri、Elisabeth Seguin、Mauro Iannelli、Thierry Besson

  DOI：10.1016/j.tetlet.2007.07.114

  日期：2007.9

  An efficient methodology for the preparation of a series of 2,3-disubstituted-quinazolin-4(3H) -ones is described via a three step reaction from anthranilic acid. The obtained results also reveal that microwave-assisted rapid decomposition of formamide under controlled conditions of power, temperature and time is a very convenient source of ammonia for the synthesis of 2-substituted-quinazolin-4(3H)-ones and other rings. (c) 2007 Elsevier Ltd. All rights reserved.