1-(2-chloro-ethoxy)-1-phenoxy-ethane | 99187-97-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(2-chloro-ethoxy)-1-phenoxy-ethane
• 英文别名: 1-(2-Chlor-aethoxy)-1-phenoxy-aethan；1-(2-Chloroethoxy)ethoxybenzene
• CAS: 99187-97-0
• 化学式: C₁₀H₁₃ClO₂
• 分子量: 200.665
• InChiKey: YUMWSLGTUFJMRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯基乙烯醚 、 2-氯乙醇 在 硫酸 作用下， 生成 1-(2-chloro-ethoxy)-1-phenoxy-ethane
  参考文献：
  名称：

  Schostakowskii et al., Zhurnal Obshchei Khimii, 1958, vol. 28, p. 2838; engl. Ausg. S. 2862

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED THIENYL-HYDROXAMIC ACIDS HAVING HISTONE DEACETYLASE ACTIVITY<br/>[FR] ACIDES HYDROXAMIQUES DE THIENYLE SUBSTITUES PRESENTANT UNE ACTIVITE DE DEACETYLASE
  申请人：ARGENTA DISCOVERY LTD

  公开号：WO2005014588A1

  公开（公告）日：2005-02-17

  A compound of formula (I): in which A represents optionally substituted monocyclic heteroaryl or phenyl B represents optionally substituted heteroaryl, aryl, aryl-fused-heterocycloalkyl, heteroaryl-fused-cycloalkyl, heteroaryl-fused-heterocycloalkyl or aryl-fused-cycloalkyl X and Y, which may be the same or different, each independently represent -0-, -NR1-, CO-, -S02-, -SO-, -S-, -NR1CO-, -NR1S02-, -CONR1-, -SO2NR1-, -NR1CONR1 or X may be a direct bond when Y represents -NR1-, -NR1CO-, -NR1SO2-, -CONR1-, - SO2NR1- or -NR1CONRI- provided that R1 represents alkyl substituted by -OR2, -NR3R4, - NR4COR5, -NR4SO2R5, -CONR3R4 or -S02NR3R4 R1 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, or alkyl substituted by -OR2, -NR3R4, -NR4COR5, -NR4S02R5, -CONR3R4 or -S02NR3R4 R2 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl or cycloalkyl R3 represents H or alkyl R4 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl or cycloalkyl or NR3R4 represents a cyclic amine R5 represents alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl n represents 0-3 m represents 1-3 p represents 0-3 and corresponding N-oxides, pharmaceutically acceptable salts, solvates and prodrugs thereof; and use to treat a disease in which inhibition of histone deacetylase can prevent, inhibit or ameliorate the pathology and/or symptomatology of the disease.

  化合物的化学式（I）：其中A代表可选择取代的单环杂环芳基或苯基，B代表可选择取代的杂环芳基、芳基、芳基-融合-杂环烷基、杂环烷基-融合-环烷基、杂环烷基-融合-杂环烷基或芳基-融合-环烷基，X和Y，可以相同也可以不同，每个独立代表-0-、-NR1-、CO-、-SO2-、-SO-、-S-、-NR1CO-、-NR1SO2-、CONR1-、-SO2NR1-、-NR1CONR1或当Y代表-NR1-、-NR1CO-、-NR1SO2-、-CONR1-、-SO2NR1-或-NR1CONRI-时，X可以是直接键，条件是R1代表由-OR2、-NR3R4、NR4COR5、NR4SO2R5、CONR3R4或-S02NR3R4取代的烷基，R1代表H、烷基、芳基烷基、杂环芳基烷基、杂环烷基烷基、环烷基烷基或由-OR2、-NR3R4、-NR4COR5、-NR4S02R5、-CONR3R4或-S02NR3R4取代的烷基，R2代表H、烷基、芳基烷基、杂环芳基烷基、杂环烷基烷基、环烷基烷基、芳基、杂环芳基、杂环烷基或环烷基，R3代表H或烷基，R4代表H、烷基、芳基烷基、杂环芳基烷基、杂环烷基烷基、环烷基烷基、芳基、杂环芳基、杂环烷基或环烷基，或NR3R4代表环胺，R5代表烷基、芳基、杂环芳基、环烷基、杂环烷基、芳基烷基、杂环芳基烷基、环烷基烷基、杂环烷基烷基，n代表0-3，m代表1-3，p代表0-3，以及相应的N-氧化物、药学上可接受的盐、溶剂合物和前药；以及用于治疗一种可以通过抑制组蛋白去乙酰化酶来预防、抑制或改善疾病的病理和/或症状的疾病。
• [EN] PRO-FLUORESCENT PROBES<br/>[FR] SONDES PRO-FLUORESCENTES
  申请人：UNIV CALIFORNIA

  公开号：WO2009152102A2

  公开（公告）日：2009-12-17

  The present invention provides a novel class of pro-fluorescent probes for reactive oxygen species (ROS). One exemplary probe is mitochondria peroxy yellow 1 (MitoPY1), a new type of flurophore for imaging mitochondrial H2O2 in living cells with ROS and spatial specificity. The invention also provides methods of using pro- fluorescent probes to detect analytes. One exemplary method comprises using a pro- fluorescent probe of the invention to detect an explosive.