3-Methoxy-3H-[1,2,3]triazolo[4,5-b]quinoline | 366004-01-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Methoxy-3H-[1,2,3]triazolo[4,5-b]quinoline
• CAS: 366004-01-5
• 化学式: C₁₀H₈N₄O
• 分子量: 200.2
• InChiKey: UKDMDQHYUPHPAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.04
• 重原子数：
  15.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  52.83
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  3-Methoxy-3H-[1,2,3]triazolo[4,5-b]quinoline 在 TEA 、 氢溴酸 、 溶剂黄146 作用下， 生成 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]quinolinium hexafluorophosphate
  参考文献：
  名称：

  The 5,6- and 4,5-Benzo Derivatives of 1-Hydroxy-7-azabenzotriazole

  摘要：

  [GRAPHICS]Syntheses of the two benzo derivatives of HOAt are described. Conversion of the two isomers to the corresponding onium-style coupling reagents gave in one case a guandinium species 14 and in the other, presumably as a result of steric factors, a uronium species 15. The two systems are compared as to their effectiveness in peptide coupling processes.

  DOI：

  10.1021/ol016063j
• 作为产物：
  描述：

  在 盐酸 、 sodium nitrite 作用下， 生成 3-Methoxy-3H-[1,2,3]triazolo[4,5-b]quinoline
  参考文献：
  名称：

  The 5,6- and 4,5-Benzo Derivatives of 1-Hydroxy-7-azabenzotriazole

  摘要：

  [GRAPHICS]Syntheses of the two benzo derivatives of HOAt are described. Conversion of the two isomers to the corresponding onium-style coupling reagents gave in one case a guandinium species 14 and in the other, presumably as a result of steric factors, a uronium species 15. The two systems are compared as to their effectiveness in peptide coupling processes.

  DOI：

  10.1021/ol016063j