6-[(3-Methoxybenzylamino)carbonyl]-3-(pyridin-2-yl)-4H-1,2,4-triazin-5-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 6-[(3-Methoxybenzylamino)carbonyl]-3-(pyridin-2-yl)-4H-1,2,4-triazin-5-one
• 英文别名: N-[(3-methoxyphenyl)methyl]-5-oxo-3-pyridin-2-yl-4H-1,2,4-triazine-6-carboxamide
• 化学式: C₁₇H₁₅N₅O₃
• 分子量: 337.338
• InChiKey: GXVQTBXFXYOGBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-吡啶氨基腙 以 甲醇 、 乙醇 为溶剂， 反应 73.0h， 生成 6-[(3-Methoxybenzylamino)carbonyl]-3-(pyridin-2-yl)-4H-1,2,4-triazin-5-one
  参考文献：
  名称：

  Synthesis and antimycobacterial activity of some 4H-1,2,4-triazin-5-one derivatives

  摘要：

  6-{(Arylmethylenamino)carbonyl]-3-(pyridin-2-yl)-4H-1,2,4-triazin-5-one derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed interesting activity against a strain of Mycobacterium tuberculosis. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(00)00074-4

文献信息

• Synthesis and antimycobacterial activity of some 4H-1,2,4-triazin-5-one derivatives
  作者：Maria Grazia Mamolo、Valeria Falagiani、Daniele Zampieri、Luciano Vio、Elena Banfi

  DOI：10.1016/s0014-827x(00)00074-4

  日期：2000.11

  6-(Arylmethylenamino)carbonyl]-3-(pyridin-2-yl)-4H-1,2,4-triazin-5-one derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed interesting activity against a strain of Mycobacterium tuberculosis. (C) 2000 Elsevier Science S.A. All rights reserved.