N-Monocarboxymethylglutaminsaeure | 41035-85-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Monocarboxymethylglutaminsaeure
• 英文别名: N-carboxymethyl-glutamic acid；N-Carboxymethyl-glutaminsaeure；2-(Carboxymethylamino)pentanedioic acid
• CAS: 41035-85-2
• 化学式: C₇H₁₁NO₆
• 分子量: 205.167
• InChiKey: YITYVXUAFSMRJI-UHFFFAOYSA-N

物化性质

• 熔点：
  155-156 °C
• 沸点：
  479.8±45.0 °C(Predicted)
• 密度：
  1.495±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  7

安全信息

• 海关编码：
  2924199090

反应信息

• 作为产物：
  描述：

  N-cyanomethyl-glutamic acid diethyl ester 在 盐酸 作用下， 生成 N-Monocarboxymethylglutaminsaeure
  参考文献：
  名称：

  Sugasawa, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1927, p. 56

  摘要：

  DOI：

文献信息

• Inflammation Inhibitor Comprising Zinc Salt of Acylamino Acid
  申请人：Iwasaki Keiji

  公开号：US20070099888A1

  公开（公告）日：2007-05-03

  An inflammation inhibitor for the skin is provided containing a zinc salt of an acylamino acid and further, a cosmetic containing the inflammation inhibitor.

  提供了一种皮肤炎症抑制剂，其包含一种酰胺酸锌盐，此外还包括一种含有该炎症抑制剂的化妆品。
• Bleaching agent
  申请人：AKZO NOBEL N.V.

  公开号：EP0992575A1

  公开（公告）日：2000-04-12

  The invention relates to alkali metal percarbonate particles having a content of active oxygen from 10 to about 15.3 wt% and comprising alkali metal silicate having a molar ratio SiO2:M2O, M being an alkali metal, exceeding 3 but not exceeding 5. The invention also relates to its preparation and use as well as a composition containing of such particles.

  本发明涉及碱金属过碳酸盐颗粒，其活性氧含量为 10 至约 15.3 wt%，并包含碱金属硅酸盐，其 SiO2:M2O 的摩尔比（M 为碱金属）超过 3 但不超过 5。本发明还涉及其制备和使用以及含有这种颗粒的组合物。
• NOVEL CYSTINE DERIVATIVES AND INHIBITORS FOR THE ACTIVATION OF INFLAMMATORY FACTORS
  申请人：Ajinomoto Co., Inc.

  公开号：EP1364943A1

  公开（公告）日：2003-11-26

  A novel cystine derivative of a specific structure, such as N,N'-bis(2-hydroxybenzyl)-L-cystine (which may be in any form of free form, salt, solvate and the like) has been found to have an excellent action to suppress the activation of inflammatory factors. By using the derivative as an effective ingredient, an excellent agent for suppressing the activation of inflammatory factors can be provided. Additionally, the cystine derivative is preferably used for a method for suppressing the activation of inflammatory factors (in particular a method for preventing, ameliorating and/or therapeutically treating diseases (disorders), or skin injuries or disorders involved in the activation of inflammatory factors, a method for preventing, delaying, ameliorating and/or therapeutically treating skin change via aging or aesthetically unfavorable skin change as induced or promoted by inflammatory factors, and the like) and for pharmaceutical agents (pharmaceutical products; external skin application agents, eye drops, nutrition agents, transfusion and the like), cosmetics, foods or drinks and the like which are specific use applications to the agent for suppressing the activation of inflammatory factors. The invention also provides the novel cystine derivative with the excellent action to suppress the activation of inflammatory factors, which can be used as the effective ingredient described above, and a method for producing the same, and additionally provides the method for suppressing the activation of inflammatory factors described above, a use of the cystine derivative (active ingredient) described above for the agent for suppressing the activation of inflammatory factors, and the like.

  研究发现，一种具有特定结构的新型胱氨酸衍生物，如 N,N'-双（2-羟基苄基）-L-胱氨酸（可以是游离态、盐、溶液等任何形式），在抑制炎症因子活化方面具有出色的作用。通过使用该衍生物作为有效成分，可以提供一种抑制炎症因子活化的极佳制剂。此外，胱氨酸衍生物优选用于抑制炎症因子活化的方法（特别是预防、改善和/或治疗涉及炎症因子活化的疾病（失调）或皮肤损伤或失调的方法，预防、延缓、改善和/或治疗由炎症因子诱发或促进的皮肤老化或美观上不利的皮肤变化的方法等）和药物制剂（医药产品；外用皮肤涂抹剂、眼药水、营养剂、输血等）、化妆品、食品或饮料等，这些都是抑制炎症因子活化的药剂的特定用途应用。 本发明还提供了具有良好抑制炎症因子活化作用、可用作上述有效成分的新型胱氨酸衍生物及其生产方法，此外还提供了上述抑制炎症因子活化的方法、上述胱氨酸衍生物（有效成分）在抑制炎症因子活化制剂中的用途等。
• COMSETICS OR EXTERNAL PREPARAIOTNS FOR SKIN
  申请人：Ajinomoto Co., Inc.

  公开号：EP1374831A1

  公开（公告）日：2004-01-02

  According to the present invention, there is provided cosmetics or external preparations for skin which comprises, as the effective ingredient, a chemical peeling agent, a bactericide, an anionic surfactant or a cationic surfactant component in combination with a compound capable of mitigating the irritation, inflammation, etc. of the skin caused by these components. The present invention is skin cosmetics, external preparations for skin or hair cosmetics which are characterized by containing the following components (A) and (B) or it is skin cosmetics or external preparations for skin which are characterized by containing the following components (C) and (D) Components (A) and (C): one or more members selected from a cystine derivative and salt thereof Component (B): one or more of members selected from a chemical peeling agent, a bactericide and an anionic surfactant Component (C): a cationic surfactant

  根据本发明，提供了用于皮肤的化妆品或外部制剂，其有效成分包括化学去皮剂、杀菌剂、阴离子表面活性剂或阳离子表面活性剂成分，以及能够减轻由这些成分引起的皮肤刺激、炎症等的化合物。 本发明是皮肤化妆品、皮肤外用制剂或头发化妆品，其特征在于含有以下成分（A）和（B），或者是皮肤化妆品或皮肤外用制剂，其特征在于含有以下成分（C）和（D）。 成分（A）和（C）：选自胱氨酸衍生物及其盐的一种或多种成分 成分（B）：一种或多种选自化学去皮剂、杀菌剂和阴离子表面活性剂的成 分 成分（C）：阳离子表面活性剂
• Water-Absorbing Agent and its Production Process and Use
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP1611949A1

  公开（公告）日：2006-01-04

  The present invention provides: a water-absorbing agent which has excellent urine resistance; a water-absorbing agent which has not only excellent urine resistance, but also excellent absorption properties that are stable to any composition of urine and show little change with time; and uses for these water-absorbing agents. The present invention water-absorbing agent exhibits a specific or larger value of absorption capacity under a load in a process in which the absorption capacity under a load is measured in a new manner using a specific liquid to be absorbed, and the present invention provides an absorbent matter which displays a specific or larger value of new absorption index as is, for example, led from the absorption capacity under a load or from the resin concentration using the above water-absorbing agent.

  本发明提供了：一种具有极佳耐尿性的吸水剂；一种不仅具有极佳耐尿性，而且对任何尿液成分都稳定且随时间变化很小的极佳吸收特性的吸水剂；以及这些吸水剂的用途。本发明的吸水剂在使用特定的待吸收液体以新的方式测量负载下的吸收能力的过程中，显示出特定的或更大的负载下的吸收能力值，本发明提供了一种吸水材料，它显示出特定的或更大的新的吸收指数值，例如，使用上述吸水剂从负载下的吸收能力或树脂浓度得出的吸收指数值。