(2-hydroxyphenyl)bis(4-methoxyphenyl)phosphine oxide | 1204570-95-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-hydroxyphenyl)bis(4-methoxyphenyl)phosphine oxide
• 英文别名: 2-Bis(4-methoxyphenyl)phosphorylphenol
• CAS: 1204570-95-5
• 化学式: C₂₀H₁₉O₄P
• 分子量: 354.342
• InChiKey: PYJVDBZLRSWVMT-UHFFFAOYSA-N

物化性质

• 熔点：
  158-160 °C
• 沸点：
  556.1±50.0 °C(Predicted)
• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2-hydroxyphenyl)bis(4-methoxyphenyl)phosphine oxide 在 三氯硅烷 、 N,N-二甲基苯胺 作用下， 以 甲苯 为溶剂， 反应 40.0h， 以72%的产率得到2-(bis(4-methyloxyphenyl)phosphino)phenol
  参考文献：
  名称：

  Alkyne Metathesis with d2 Re(V) Alkylidyne Complexes Supported by Phosphino-Phenolates: Ligand Effect on Catalytic Activity and Applications in Ring-Closing Alkyne Metathesis,d2 Re(V) 炔烃复合物与膦基酚盐支持的炔烃复分解：配体对催化活性的影响及其在闭环炔烃复分解中的应用

  摘要：

  A family of d2 Re(V) alkylidyne complexes bearing two decorated phosphino-phenolates (POs) and a labile pyridine ligand were prepared that can efficiently promote alkyne metathesis reactions in toluene. The relative activity of these complexes varies with the PO ligands. Complexes with an electron-rich metal center have a higher activity. Ligand exchange experiments suggest that the pyridine ligands

  DOI：

  10.1021/jacs.2c00368
• 作为产物：
  描述：

  ethyl bis(4-methoxyphenyl)phosphinate 在 四丁基二氟三苯硅酸铵 、 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 6.0h， 生成 (2-hydroxyphenyl)bis(4-methoxyphenyl)phosphine oxide
  参考文献：
  名称：

  将Arynes插入P–O键：C–P和C–O键的一步同时构建

  摘要：

  描述了将芳烃插入到P–O键中以制备邻羟基取代的芳基膦氧化物，-次膦酸酯和-膦酸酯。这种新颖的反应可以一步一步同时形成C-P和C-O键，在温和且无过渡金属的条件下，具有良好的收率和区域选择性。所得邻羟基的容易的后续转化将这些反应扩展到其他邻位取代的芳基磷化合物的容易构造。

  DOI：

  10.1021/acs.orglett.6b03283

文献信息

• Pd-Catalyzed Reactions of Allenylphosphonates and Related Allenes with Functionalized 2-Iodophenols, 2-Iodobenzoic Acid, and 2-Iodobenzyl Alcohol Leading to Functionalized Benzofurans, Isocoumarins, and Benzopyrans
  作者：M. Phani Pavan、Manab Chakravarty、K. C. Kumara Swamy

  DOI：10.1002/ejoc.200900865

  日期：2009.12

  (1H/31P NMR) in reactions by using functionalized iodophenols, essentially as single isomers. The synthetic potential of these products possessing an aldehyde functionality is demonstrated by isolating a compound with the skeleton of Obovaten and many other 2,3,5,7-tetrasubstituted benzofurans. From the reaction of 2-iodophenol and PdII(OAc)2/PAr3, isolation and structural characterization of the (hydroxy)aryl

  烯基膦酸酯 (OCH2CMe2CH2O)P(O)CH=C=CRR' [R, R' = H (1a), R = H, R' = Me (1b), R = R' = 的区域选择性钯催化偶联反应Me (1c)] 和苯基丙二烯 PhCH=C=CR2 [R = H (2a), Me (2b)] 与官能化碘酚（在 PEG-400 中）、2-碘苯甲酸和 2-碘苯甲醇进行了研究。具有游离醛官能团的苯并呋喃在反应中通过使用官能化碘苯酚以高产率 (1H/31P NMR) 形成，基本上作为单一异构体。通过分离具有 Obovaten 和许多其他 2,3,5,7-四取代苯并呋喃骨架的化合物，证明了这些具有醛官能团的产品的合成潜力。从 2-碘苯酚和 PdII(OAc)2/PAr3 的反应，分离和结构表征 (羟基) 芳基氧化膦 (Ar)2P(O)(C6H4-2-OH) (Ar = Ph, 4-MeOC6H4) 表明 P-芳基到
• Insertion of Arynes into P–O Bonds: One-Step Simultaneous Construction of C–P and C–O Bonds
  作者：Na Qi、Ning Zhang、Srinivasa Rao Allu、Jiangsheng Gao、Jian Guo、Yun He

  DOI：10.1021/acs.orglett.6b03283

  日期：2016.12.2

  The insertion of arynes into P–O bonds for the preparation of o-hydroxy-substituted arylphosphine oxides, -phosphinates, and -phosphonates is described. This novel reaction leads to the simultaneous formation of C–P and C–O bonds in one step with good yields and regioselectivities under mild and transition-metal-free conditions. The easy follow-up transformations of the resulting o-hydroxyl group extend

  描述了将芳烃插入到P–O键中以制备邻羟基取代的芳基膦氧化物，-次膦酸酯和-膦酸酯。这种新颖的反应可以一步一步同时形成C-P和C-O键，在温和且无过渡金属的条件下，具有良好的收率和区域选择性。所得邻羟基的容易的后续转化将这些反应扩展到其他邻位取代的芳基磷化合物的容易构造。
• Alkyne Metathesis with d²Re(V) Alkylidyne Complexes Supported by Phosphino-Phenolates: Ligand Effect on Catalytic Activity and Applications in Ring-Closing Alkyne Metathesis
  作者：Mingxu Cui、Herman H. Y. Sung、Ian D. Williams、Guochen Jia

  DOI：10.1021/jacs.2c00368

  日期：2022.4.13

  Re(V) alkylidyne complexes bearing two decorated phosphino-phenolates (POs) and a labile pyridine ligand were prepared that can efficiently promote alkyne metathesis reactions in toluene. The relative activity of these complexes varies with the PO ligands. Complexes with an electron-rich metal center have a higher activity. Ligand exchange experiments suggest that the pyridine ligands of the Re(V) alkylidynes

  A family of d2 Re(V) alkylidyne complexes bearing two decorated phosphino-phenolates (POs) and a labile pyridine ligand were prepared that can efficiently promote alkyne metathesis reactions in toluene. The relative activity of these complexes varies with the PO ligands. Complexes with an electron-rich metal center have a higher activity. Ligand exchange experiments suggest that the pyridine ligands