(phenylacetyl)isoglutamine | 104771-88-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (phenylacetyl)isoglutamine
• 英文别名: N²-phenylacetyl-DL-isoglutamine；5-Amino-5-oxo-4-[(2-phenylacetyl)amino]pentanoic acid
• CAS: 104771-88-2
• 化学式: C₁₃H₁₆N₂O₄
• 分子量: 264.281
• InChiKey: XBJLFHMAIQTBJX-UHFFFAOYSA-N

物化性质

• 沸点：
  639.6±55.0 °C(Predicted)
• 密度：
  1.279±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氨 作用下， 生成 (phenylacetyl)isoglutamine
  参考文献：
  名称：

  Anhydrophenacetylglutamic Acid

  摘要：

  DOI：

  10.1021/ja01140a066

文献信息

• Methods for the treatment of recurrent glioblastoma (RGBM)
  申请人：Burzynski Stanislaw R.

  公开号：US10624869B2

  公开（公告）日：2020-04-21

  Methods for the treatment of cancer, including glioblastoma multiforme (GBM) and recurrent glioblastoma multiforme (RGBM). The method includes administering to a patient a plurality of extraneous antineoplastons and a plurality of targeted agents. The plurality of extraneous antineoplastons may include two or more antineoplastons selected from phenylacetylglutaminate sodium (PG), phenylacetylisoglutaminate sodium (iso-PG), and phenylacetate (PN). The plurality of targeted agents may include two or more agents selected from bevacizumab, pazopanib, sorafenib, dasatinib, and everolimus.

  治疗癌症的方法，包括多形性胶质母细胞瘤（GBM）和复发性多形性胶质母细胞瘤（RGBM）。该方法包括向患者施用多种外来抗肿瘤药物和多种靶向药物。多种外来抗肿瘤药物可包括选自苯乙酰谷氨酸钠（PG）、苯乙酰异谷氨酸钠（iso-PG）和苯乙酸盐（PN）的两种或多种抗肿瘤药物。多种靶向药物可包括两种或两种以上选自贝伐珠单抗、帕佐帕尼、索拉非尼、达沙替尼和依维莫司的药物。
• Methods for the treatment of glioblastoma multiforme
  申请人：Burzynski Stanislaw R.

  公开号：US11234951B2

  公开（公告）日：2022-02-01

  Methods for the treatment of cancer, including glioblastoma multiforme (GBM) and recurrent glioblastoma multiforme (RGBM). The method includes administering to a patient a plurality of extraneous antineoplastons and a plurality of targeted agents. The plurality of extraneous antineoplastons may include two or more antineoplastons selected from phenylacetylglutaminate sodium (PG), phenylacetylisoglutaminate sodium (iso-PG), and phenylacetate (PN). The plurality of targeted agents may include two or more agents selected from bevacizumab, pazopanib, sorafenib, dasatinib, and everolimus.

  治疗癌症的方法，包括多形性胶质母细胞瘤（GBM）和复发性多形性胶质母细胞瘤（RGBM）。该方法包括向患者施用多种外来抗肿瘤药物和多种靶向药物。多种外来抗肿瘤药物可包括选自苯乙酰谷氨酸钠（PG）、苯乙酰异谷氨酸钠（iso-PG）和苯乙酸盐（PN）的两种或多种抗肿瘤药物。多种靶向药物可包括两种或两种以上选自贝伐珠单抗、帕佐帕尼、索拉非尼、达沙替尼和依维莫司的药物。
• Methods for the treatment of leptomeningeal disease
  申请人：Burzynski Research Institute, Inc.

  公开号：US11344521B2

  公开（公告）日：2022-05-31

  Methods for the treatment of leptomeningeal disease in a pediatric patient. The leptomeningeal disease may be leptomeningeal, disseminated, and/or multicentric disease (LDM) and may be associated with one or more primary CNS tumors or one or more low-grade gliomas (LGGs). The method includes administering to a patient a plurality of extraneous antineoplastons.

  治疗小儿脑膜疾病的方法。脑膜疾病可能是脑膜疾病、播散性疾病和/或多中心疾病（LDM），可能与一种或多种原发性中枢神经系统肿瘤或一种或多种低级别胶质瘤（LGG）有关。该方法包括向患者施用多种外源性抗肿瘤药物。
• 3-[(Phenylacetyl)amino]-2,6-piperidinedione Hydrolysis Studies with Improved Synthesis and Characterization of Hydrolysates
  作者：Larry K. Revelle、D. André d'Avignon、Joe A. Wilson

  DOI：10.1021/js960120y

  日期：1996.10

  In an attempt to clarify ambiguities in earlier reports on the preclinical chemistry of Antineoplaston A10 (3-[(phenylacetyl)amino]-2,6-piperidinedione; PAP), we detail herein hydrolysis studies with improved synthesis and characterization of PAP hydrolysis products, (phenylacetyl)glutamine (PAG), (phenylacetyl)isoglutamine (PAIG), and (phenylacetyl)glutamic acid (PAGA). Flash chromatography proved superior to extraction in the isolation of synthetic standards and hydrolysates. Synthesis of PAIG directly from commercial isoglutamine showed consistently better yields than the previously reported method. The H-1 and C-13 NMR and HPLC-MS data from the synthesized standards matched the data from the isolated PAP hydrolysates formed under acid and alkaline degradation conditions. Multiple quantum coherence NMR methods (HMQC and HMBC) and HPLC-MS-MS methods were applied to provide unambiguous structural assignments for key isomers PAG and PAIG. Previous PAP hydrolysis studies are shown to be reproducible, and the structures of hydrolysis products are elucidated in detail.
• 255. N-(N-phenylacetyl-α-<scp>DL</scp>-glutamyl)-<scp>D</scp>-penicillamine
  作者：Wilson Baker、P. G. Jones

  DOI：10.1039/jr9510001143

  日期：——