2-乙基-4-硝基苯甲醚 | 90610-18-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-乙基-4-硝基苯甲醚
• 英文名称: 5-Nitro-2-methoxy-1-ethyl-benzol
• 英文别名: Benzene, 2-ethyl-1-methoxy-4-nitro-；2-ethyl-1-methoxy-4-nitrobenzene
• CAS: 90610-18-7
• 化学式: C₉H₁₁NO₃
• 分子量: 181.191
• InChiKey: TUWCJWLEBXKNJD-UHFFFAOYSA-N

物化性质

• 沸点：
  294.8±20.0 °C(Predicted)
• 密度：
  1.146±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-乙基-4-硝基苯甲醚 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 3-ethyl-4-methoxyaniline
  参考文献：
  名称：

  甲状腺激素药。I.一些3'和3'，5'-烷基和ARYL-3,5-二碘代酪氨酸的合成和低胆固醇活性。

  摘要：

  DOI：

  10.1021/jm00341a020
• 作为产物：
  描述：

  2-乙基苯甲醚 在 硝酸 作用下， 反应 0.5h， 生成 2-乙基-4-硝基苯甲醚 、 1-Ethyl-2-methoxy-3-nitrobenzene
  参考文献：
  名称：

  苯并氧杂杂环的乙酰化，溴化和硝化以及由乙酰基衍生物合成β-氨基酮

  摘要：

  DOI：

  10.1007/bf00513564

文献信息

• Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
  申请人：Akerman Michelle

  公开号：US20070142384A1

  公开（公告）日：2007-06-21

  The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L 1 -P-L 2 -M-X-L 3 -A wherein the definitions of the variables Q, L 1 , P, L 2 , M, X, L 3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

  本发明提供了一些化合物，例如用于调节受试者胰岛素水平的化合物，其具有以下一般式Q-L1-P-L2-M-X-L3-A，其中变量Q、L1、P、L2、M、X、L3和A的定义在此处提供。本发明还提供了该化合物的组合物和使用该化合物的方法，例如治疗II型糖尿病。
• BIS-QUARTERNARY CINCHONA ALKALOID SALTS AS ASYMMETRIC PHASE TRANSFER CATALYSTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150031891A1

  公开（公告）日：2015-01-29

  The invention is directed to novel bis-quarternary cinchona alkaloid salts and the use of bis-quarternary cinchona alkaloid salts in asymmetric phase transfer catalysis. The present invention is directed to novel bis-quarternary cinchona alkaloid salts and the use of bis-quarternary cinchona alkaloid salts in asymmetric phase transfer catalysis. On certain substrates and under specific reaction conditions, the inventors have discovered that the use of bis-quarternary cinchona alkaloid salts in asymmetric phase transfer catalysis surprisingly provides for a more active and efficient process as compared to mono-quarternary catalysts.

  本发明涉及新型的双季铵喜树碱盐以及在不对称相转移催化中使用双季铵喜树碱盐。本发明涉及新型的双季铵喜树碱盐以及在不对称相转移催化中使用双季铵喜树碱盐。在某些底物和特定反应条件下，发明人发现与单季铵催化剂相比，使用双季铵喜树碱盐在不对称相转移催化中出人意料地提供了更活跃和高效的过程。
• Benzimidazole derivatives and their use as a medicament
  申请人：Poitout Lydie

  公开号：US20090170922A1

  公开（公告）日：2009-07-02

  A subject of the present application is new benzimidazole derivatives of formula in which A, Y, R 1 , R 2 , R 3 and R 4 represent different variable groups. These products have an antagonist activity of GnRH (Gonadotropin-Releasing Hormone). The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament.

  本申请的主题是公式中A、Y、R1、R2、R3和R4代表不同变量基团的新苯并咪唑衍生物。这些产物具有GnRH（促性腺激素释放激素）的拮抗活性。本发明还涉及含有所述产物的制药组合物及其用于制备药物的用途。
• Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes
  申请人：RIKER LABORATORIES, INC.

  公开号：EP0310950A1

  公开（公告）日：1989-04-12

  Compounds of the types (I) and (II) are disclosed, wherein each R₅ is independently selected from the group consisting of alkyl of one to about four carbon atoms, alkoxy of one to about four carbon atoms and halogen, and n is an integer from 0 to 2, with the proviso that if n is 2, then said R₅ substituents together contain no more than 6 carbon atoms; R₆ is selected from the group consisting of hydroxyalkyl of one to about six carbon atoms and cyclohexyl­methyl; and R₇ is selected from the group consisting of alkyl of one to about four carbon atoms and hydrogen. These compounds may be used as intermediates for the synthesis of 1H-imidazo[4,5-c]quinoline derivatives.

  本发明公开了(I)和(II)型化合物、 其中每个 R₅ 独立地选自由 1 至约 4 个碳原子的烷基、1 至约 4 个碳原子的烷氧基和卤素组成的组，且 n 为 0 至 2 的整数，但如果 n 为 2，则所述 R₅ 取代基合在一起所含的碳原子数不超过 6；R₆ 选自由 1 至约 6 个碳原子的羟基烷基和环己基甲基组成的组；以及 R₇ 选自由 1 至约 4 个碳原子的烷基和氢组成的组。 这些化合物可用作合成 1H-咪唑并[4,5-c]喹啉衍生物的中间体。
• Formation of nitrophenyl ethers from polyols and nitroanisoles
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0335274A2

  公开（公告）日：1989-10-04

  Disclosed is a novel process for effecting an ether interchange reaction by heating together in the presence of a basic catalyst, a nitroaromatic ether or thioether and an organic compound containing at least one hydroxyl or mercapto group. The novelty resides particularly in carrying out the interchange in an inert solvent while sparging the heated reactants thereby to remove at least a portion of solvent along with an evolving alcohol or thiol. The process is particularly adapted to the capping of organic polyols with nitroaromatic ether groups. The capped products are useful as inter­mediates for the preparation of high molecular weight polyamines which in turn find utility in various polymer applications.

  本发明公开了一种新工艺，在碱性催化剂存在下，将硝基芳香族醚或硫醚和含有至少一个羟基或巯基的有机化合物一起加热，从而进行醚互换反应。新颖之处尤其在于在惰性溶剂中进行交换反应，同时对加热的反应物进行喷射，以除去至少一部分溶剂和挥发的醇或硫醇。 该工艺特别适用于有机多元醇与硝基芳香族醚基团的封端。封端的产品可用作制备高分子量多胺的中间体，而高分子量多胺又可用于各种聚合物应用。