dimorpholino-3-methylphenylmethane | 1257404-88-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dimorpholino-3-methylphenylmethane
• 英文别名: 4-[(3-Methylphenyl)-morpholin-4-ylmethyl]morpholine
• CAS: 1257404-88-8
• 化学式: C₁₆H₂₄N₂O₂
• 分子量: 276.379
• InChiKey: XJUICUHSVBGHCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  dimorpholino-3-methylphenylmethane 、 对硝基苯甲酰胺 反应 0.12h， 以66%的产率得到N-[(3-methylphenyl)-morpholin-4-ylmethyl]-4-nitrobenzamide
  参考文献：
  名称：

  Solvent-free synthesis of monoacylaminals from the reaction of amides and aminals as precursors in carbinolamide synthesis

  摘要：

  A solvent-free method of generating monoacylaminals by heating the amide and aminal starting materials in the presence of one another has been developed. Yields were generally between 45% and 65% with the monoacylaminal being isolated, needing no further purification after drying under high vacuum. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.043
• 作为产物：
  描述：

  吗啉 、 3-甲基苯甲醛 以 苯 为溶剂， 以74%的产率得到dimorpholino-3-methylphenylmethane
  参考文献：
  名称：

  Solvent-free synthesis of monoacylaminals from the reaction of amides and aminals as precursors in carbinolamide synthesis

  摘要：

  A solvent-free method of generating monoacylaminals by heating the amide and aminal starting materials in the presence of one another has been developed. Yields were generally between 45% and 65% with the monoacylaminal being isolated, needing no further purification after drying under high vacuum. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.043

文献信息

• Silver-catalyzed nucleophilic substitution of aminals with ethyl diazoacetate: a new pathway to β-amino-α-diazoesters
  作者：Jiawen Li、Guiping Qin、Hanmin Huang

  DOI：10.1039/c6ob02136k

  日期：——

  A novel silver-catalyzed nucleophilic substitution of aminals with ethyl diazoacetate producing β-amino-α-diazoesters has been developed. A series of aminals with different amino moieties and substituents were successfully incorporated in this reaction, which delivered a wide range of β-amino-α-diazocarbonyl compounds in the presence of a lower catalyst loading in 2 hours.

  已经开发了用重氮乙酸乙酯产生β-氨基-α-重氮酸酯的新颖的银催化的氨基苯胺亲核取代。一系列具有不同氨基部分和取代基的缩醛被成功地加入到该反应中，在2小时内催化剂负载量较低的情况下，该缩醛化合物可提供多种β-氨基-α-重氮羰基化合物。
• US5442029A
  申请人：——

  公开号：US5442029A

  公开（公告）日：1995-08-15
• Solvent-free synthesis of monoacylaminals from the reaction of amides and aminals as precursors in carbinolamide synthesis
  作者：Matthew F. Sansone、Takaoki Koyanagi、David E. Przybyla、Richard W. Nagorski

  DOI：10.1016/j.tetlet.2010.09.043

  日期：2010.11

  A solvent-free method of generating monoacylaminals by heating the amide and aminal starting materials in the presence of one another has been developed. Yields were generally between 45% and 65% with the monoacylaminal being isolated, needing no further purification after drying under high vacuum. (C) 2010 Elsevier Ltd. All rights reserved.