O-propionyl-2,3-dichlorophenol | 777067-71-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: O-propionyl-2,3-dichlorophenol
• 英文别名: 2,3-Dichlorophenyl propionate；(2,3-dichlorophenyl) propanoate
• CAS: 777067-71-7
• 化学式: C₉H₈Cl₂O₂
• mdl: MFCD25969940
• 分子量: 219.067
• InChiKey: FWYDTBSPIFJITG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  O-propionyl-2,3-dichlorophenol 在 tris(dibenzylideneacetone)dipalladium (0) 三氯化铝 、 盐酸羟胺 、 caesium carbonate 、 三环己基膦 作用下， 以 1,4-二氧六环 、 乙醇 、 甲苯 为溶剂， 反应 55.0h， 生成
  参考文献：
  名称：

  Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands

  摘要：

  3,4-diphenylsalicylaldoxime and 3,4-diphenylanthranylaldoxime derivatives, containing small groups (methyl or ethyl) on the imine carbon atom, were synthesized and submitted to biological assays. Binding tests performed on uterine cytosol estrogen receptor (ER) preparation and on purified full-length human ERalpha and ERbeta, showed that the newly synthesised compounds exhibit considerably lower binding affinities with respect to reference non-substituted 3,4-salicylaldoxime.

  DOI：

  10.1016/j.farmac.2004.01.007
• 作为产物：
  描述：

  二氯-苯酚 、 丙酰氯 在 sodium hydroxide 、 四丁基硫酸氢铵 作用下， 以 1,4-二氧六环 为溶剂， 以30%的产率得到O-propionyl-2,3-dichlorophenol
  参考文献：
  名称：

  Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands

  摘要：

  3,4-diphenylsalicylaldoxime and 3,4-diphenylanthranylaldoxime derivatives, containing small groups (methyl or ethyl) on the imine carbon atom, were synthesized and submitted to biological assays. Binding tests performed on uterine cytosol estrogen receptor (ER) preparation and on purified full-length human ERalpha and ERbeta, showed that the newly synthesised compounds exhibit considerably lower binding affinities with respect to reference non-substituted 3,4-salicylaldoxime.

  DOI：

  10.1016/j.farmac.2004.01.007

文献信息

• Tetrahydronaphthalene derivates, processes for preparing them and their use as antiinflammatory agents
  申请人：Berger Markus

  公开号：US20070225290A1

  公开（公告）日：2007-09-27

  The invention relates to multiply substituted tetrahydronaphthalene derivatives of the formula (Ia) to processes for preparing them and to their use as antiinflammatory agents.

  该发明涉及公式(Ia)的多取代四氢萘衍生物，以及制备它们的过程和它们作为抗炎药物的用途。
• Tetrahydronaphthalene derivatives, methods for the production thereof, and the use thereof as antiphlogistics
  申请人：Bayer Schering Pharma AG

  公开号：US07880042B2

  公开（公告）日：2011-02-01

  The invention relates to multiply substituted tetrahydronaphthalene derivatives of the formula (Ia) to processes for preparing them and to their use as antiinflammatory agents.

  该发明涉及公式（Ia）的多取代四氢萘衍生物，以及制备它们的方法和作为抗炎药物的用途。
• TETRAHYDRONAPHTHALENE DERIVATES, PROCESS FOR PREPARING THEM AND THEIR USE AS ANTIINFLAMMATORY AGENTS
  申请人：BERGER Markus

  公开号：US20100298311A1

  公开（公告）日：2010-11-25

  The invention relates to multiply substituted tetrahydronaphthalene derivatives of the formula (Ia) to processes for preparing them and to their use as antiinflammatory agents.

  本发明涉及一种多取代四氢萘衍生物，其化学式为(Ia)，以及制备它们的过程和将它们用作抗炎剂的用途。
• Process for the preparation of copolymers of ethylene with at least one other 1-alkene
  申请人：STAMICARBON B.V.

  公开号：EP0044119A2

  公开（公告）日：1982-01-20

  Process for the preparation of copolymers consisting of 25-85% by wt. of ethylene, 15-75% by wt. of at least one other 1-alkene and optionally up to 20% by wt. of a polyunsaturated compound with application of a catalyst system containing a compound of a metal from sub-groups IV-VI of the periodic system and a compound of a metal from groups I-III of the periodic system, in which at least one hydrocarbon group is bound directly to the metal atom via a carbon atom, the polymerization being carried out in the presence of a halogen-containing compound of the general formula where A is a phenyl group which may contain one or two substituent halogen atoms or alkyl groups, or is a thienyl, furyl, pyrollyl, N-alkylpyrollyl or pyridyl group, which group is bound to the carbon atom directly or via a carbonyl group, X is a chlorine or bromine atom, Y is a chlorine, bromine or hydrogen atom or a hydrocarbon group with 1-8 carbon atoms, and Z is a nitrile group, a carboxyl group, an ester group, a hydrocarbyloxyalkylcarboxyl group, an carboxylic acid halide group, an amide group, a benzoyl group, a carboxyphenyl group or a carboxylhydrocarbylphenyl group.

  制备由 25-85%（重量百分比）乙烯、15-75%（重量百分比）至少一种其他 1-烯烃和（任选）最多 20%（重量百分比）多不饱和化合物组成的共聚物的工艺，其中催化剂体系含有周期系第Ⅳ-Ⅵ亚族金属化合物和周期系第Ⅰ-Ⅲ族金属化合物。聚合反应是在通式如下的含卤素化合物存在下进行的 其中 A 是苯基，可含有一个或两个取代卤素原子或烷基，或者是噻吩基、呋喃基、吡咯基、 N-烷基吡咯基或吡啶基，该基团直接或通过羰基与碳原子结合；X 是氯原子或溴原子；Y 是氯、Z 为腈基、羧基、酯基、烃基羧基、羧酸卤化基、酰胺基、苯甲酰基、羧基苯基或羧基氢羧基苯基。
• Copolymers of ethylene and an alpha-olefin and catalytic production thereof
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0346098A2

  公开（公告）日：1989-12-13

  Ethylene (35-60 mols) and a C3-10 a-olefin (65-40 mols) are copolymerized at a temperature of 40 to 80°C with a catalyst of (a) an oxyvanadium compound, (b) an organoaluminium compound and (c) a halogenated hydrocarbon ester, e.g. a perchlorocrotonic acid ester, in a mol ratio of (b) to (a) of ≧ 2.5 and of (c) to (a) of ≧ 1.5, in a hydrocarbon solvent. The polymer has a molar ratio of ethylene: a-olefin of 88:12 - 98:2, a number average mol. wt. of 35,000 - 80,000 and a ratio of wt. number average mol wt. of 1.8:1 - 3.0:1 determined by GPC. It has good transparency and is moldable to a film which is heat-sealable at low temperature.

  乙烯(35-60 摩尔)和 C3-10 a-烯烃(65-40 摩尔)在 40 至 80℃的温度下与(a)氧钒化合物、(b)有机铝化合物和(c)卤代烃酯(如全氯酸酯)催化剂共聚，(b)与(a)的摩尔比≧ 2.5，(c)与(a)的摩尔比≧ 1.5。(b)与(a)的摩尔比≧2.5，(c)与(a)的摩尔比≧1.5。 经 GPC 测定，该聚合物的乙烯：a-烯烃摩尔比为 88:12 - 98:2，平均摩尔重量为 35,000 - 80,000，重量比为 1.8:1 - 3.0:1。它具有良好的透明度，可模塑成薄膜，并可在低温下热封。