N-tert-butyl-17α-hydroxy-3-oxoandrost-4-ene-17β-carboxamide | 206351-37-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: N-tert-butyl-17α-hydroxy-3-oxoandrost-4-ene-17β-carboxamide
• 英文别名: (8R,9S,10R,13S,14S,17R)-N-tert-butyl-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17-carboxamide
• CAS: 206351-37-3
• 化学式: C₂₄H₃₇NO₃
• 分子量: 387.563
• InChiKey: HOYIDGJPRPKOSF-PDUMRIMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.16
• 重原子数：
  28.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  66.4
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  N-tert-butyl-17α-hydroxy-3-oxoandrost-4-ene-17β-carboxamide 在 potassium permanganate 、 sodium periodate 、 sodium carbonate 作用下， 以 水 、 叔丁醇 为溶剂， 反应 0.08h， 以78.93%的产率得到3-[(3R,3aS,5aS,6R,9aS,9bS)-3-(tert-butylcarbamoyl)-3-hydroxy-3a,6-dimethyl-7-oxo-2,4,5,5a,8,9,9a,9b-octahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid
  参考文献：
  名称：

  Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes

  摘要：

  An N-aryl-3-oxo-4-aza-5 alpha-androst-1-ene-17 beta-carboxamide and three N-aryl or alkyl substituted 17 alpha-hydroxy-3-oxo-4-aza-5 alpha -androstane-17 beta-carboxamides were synthesized as antiandrogen candidates from 3-oxoandrost-4-ene-17 beta-carboxylic acid and androst-4-ene-3,17-dione respectively. The chemo- and stereoselective reduction of 3-oxo-4-aza-5-ene intermediates with formic acid and their tautomerism in a solution of chloroform and methanol were described.

  DOI：

  10.3987/com-97-s(n)35
• 作为产物：
  描述：

  17 α-hydroxyprogesterone 在 氯化亚砜 作用下， 以 吡啶 、 甲苯 为溶剂， 反应 3.5h， 生成 N-tert-butyl-17α-hydroxy-3-oxoandrost-4-ene-17β-carboxamide
  参考文献：
  名称：

  Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes

  摘要：

  An N-aryl-3-oxo-4-aza-5 alpha-androst-1-ene-17 beta-carboxamide and three N-aryl or alkyl substituted 17 alpha-hydroxy-3-oxo-4-aza-5 alpha -androstane-17 beta-carboxamides were synthesized as antiandrogen candidates from 3-oxoandrost-4-ene-17 beta-carboxylic acid and androst-4-ene-3,17-dione respectively. The chemo- and stereoselective reduction of 3-oxo-4-aza-5-ene intermediates with formic acid and their tautomerism in a solution of chloroform and methanol were described.

  DOI：

  10.3987/com-97-s(n)35