[1-(2-Methoxy-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine | 103667-21-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: [1-(2-Methoxy-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine
• CAS: 103667-21-6
• 化学式: C₁₇H₁₉NO
• 分子量: 253.344
• InChiKey: VGZHFCYNXIFZHS-SUXRJGGNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.27
• 重原子数：
  19.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  21.59
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  [1-(2-Methoxy-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine 生成 N-<1(S)-(2-methoxyphenyl)ethyl>-1-(S)-phenylethylamine
  参考文献：
  名称：

  ELEVELD, M. B.;HOGEVEEN, H., TETRAHEDRON LETT., 1984, 25, N 45, 5187-5190

  摘要：

  DOI：
• 作为产物：
  描述：

  (S)-(-)- α-甲基苄胺 、 2'-甲氧基苯乙酮 生成 [1-(2-Methoxy-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine
  参考文献：
  名称：

  ELEVELD, M. B.;HOGEVEEN, H., TETRAHEDRON LETT., 1984, 25, N 45, 5187-5190

  摘要：

  DOI：

文献信息

• Highly Diastereoselective Hydrogenation of Imines by a Bimetallic Pd−Cu Heterogeneous Catalyst
  作者：Jale Müslehiddinoğlu、Jun Li、Srinivas Tummala、Rajendra Deshpande

  DOI：10.1021/op1001325

  日期：2010.7.16

  An efficient and practical heterogeneous bimetallic Pd-Cu/C catalyst was identified as an alternative to Raney nickel for the highly diastereoselective hydrogenation of imines prepared from prochiral ketones and alpha-phenylethylamines. Chiral amines were obtained with diastereomeric excess (de) up to 94% using Pd-Cu/C, while conventional Pd-C catalysts afforded only 72% de. Optimization showed that a robust process required a palladium/copper ratio of 4:1. Evidence for the influence of catalyst pretreatment which may change the structure of the catalyst and/or metal oxidation states on the selectivity of the reaction is discussed. The bimetallic catalyst system provided consistent results on scale and performed reliably on a variety of substrates.
• Diastereoselective synthesis of chiral secondary amines with two chiral centers directly attached to the nitrogen atom
  作者：M. B. Eleveld、H. Hogeveen、E. P. Schudde

  DOI：10.1021/jo00369a016

  日期：1986.9
• ELEVELD M. B.; HOGEVEEN H.; SCHUDDE E. P., J. ORG. CHEM., 51,(1986) N 19, 3635-3642
  作者：ELEVELD M. B.、 HOGEVEEN H.、 SCHUDDE E. P.

  DOI：——

  日期：——