N,N',N'',N'''-((((methylenebis(4,1-phenylene))bis(azaneylylidene))bis(methanediylylidene))tetrakis(benzene-4,1-diyl))tetrakis(2,2,2-trichloroacetamide) | 1001130-36-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N',N'',N'''-((((methylenebis(4,1-phenylene))bis(azaneylylidene))bis(methanediylylidene))tetrakis(benzene-4,1-diyl))tetrakis(2,2,2-trichloroacetamide)
• CAS: 1001130-36-4
• 化学式: C₄₇H₃₀Cl₁₂N₆O₄
• 分子量: 1168.23
• InChiKey: LJKNPEGXKBXUTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.85
• 重原子数：
  69.0
• 可旋转键数：
  12.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  141.12
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  N,N',N'',N'''-((((methylenebis(4,1-phenylene))bis(azaneylylidene))bis(methanediylylidene))tetrakis(benzene-4,1-diyl))tetrakis(2,2,2-trichloroacetamide) 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以95%的产率得到
  参考文献：
  名称：

  Divergent Approach for Synthesis and Terminal Modifications of Dendritic Polyphenylazomethines

  摘要：

  In the past, dendritic polyphenylazomethines (DPA) have been synthesized via the convergent method. However, the convergent method has problems such as difficult terminal-group modifications and an increased number of steps. Therefore, we synthesized the terminal-protected DPA to construct the dendritic structure via the divergent method. The combination of the convergent method and the divergent method easily achieved the rapid synthesis of a higher generation dendrimer. Furthermore, we succeeded in the synthesis of the water-soluble PEG-DPA via the divergent method using the ester-DPA.

  DOI：

  10.1021/ol701925a
• 作为产物：
  描述：

  4,4'-di(trichloroacetamido)benzophenone 、 4,4'-二氨基二苯甲烷 在 三乙烯二胺 、 四氯化钛 作用下， 以 氯苯 为溶剂， 反应 1.5h， 以87%的产率得到N,N',N'',N'''-((((methylenebis(4,1-phenylene))bis(azaneylylidene))bis(methanediylylidene))tetrakis(benzene-4,1-diyl))tetrakis(2,2,2-trichloroacetamide)
  参考文献：
  名称：

  Divergent Approach for Synthesis and Terminal Modifications of Dendritic Polyphenylazomethines

  摘要：

  In the past, dendritic polyphenylazomethines (DPA) have been synthesized via the convergent method. However, the convergent method has problems such as difficult terminal-group modifications and an increased number of steps. Therefore, we synthesized the terminal-protected DPA to construct the dendritic structure via the divergent method. The combination of the convergent method and the divergent method easily achieved the rapid synthesis of a higher generation dendrimer. Furthermore, we succeeded in the synthesis of the water-soluble PEG-DPA via the divergent method using the ester-DPA.

  DOI：

  10.1021/ol701925a