Ethyl 3-(3,5-dibromo-4-hydroxyphenyl)-2-ethoxypropanoate | 544478-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Ethyl 3-(3,5-dibromo-4-hydroxyphenyl)-2-ethoxypropanoate
• 英文别名: ethyl 3-(3,5-dibromo-4-hydroxyphenyl)-2-ethoxypropanoate
• CAS: 544478-45-7
• 化学式: C₁₃H₁₆Br₂O₄
• 分子量: 396.076
• InChiKey: QPMAXYNBYZCYFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Ethyl 3-(3,5-dibromo-4-hydroxyphenyl)-2-ethoxypropanoate 在 sodium carbonate 、 potassium carbonate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 42.0h， 生成 3-[3,5-Dibromo-4-[2-(3-oxothieno[3,2-b][1,4]oxazin-4-yl)ethoxy]phenyl]-2-ethoxypropanoic acid
  参考文献：
  名称：

  Novel thieno oxazine analogues as antihyperglycemic and lipid modulating agents

  摘要：

  A series of phenyl acetic acid and alpha-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00976-9
• 作为产物：
  描述：

  4-苄氧基苯甲醛 在 palladium on activated charcoal N-溴代丁二酰亚胺(NBS) 、 氢气 、 sodium hydride 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 四氯化碳 为溶剂， 60.0 ℃ 、413.68 kPa 条件下， 反应 3.0h， 生成 Ethyl 3-(3,5-dibromo-4-hydroxyphenyl)-2-ethoxypropanoate
  参考文献：
  名称：

  Novel thieno oxazine analogues as antihyperglycemic and lipid modulating agents

  摘要：

  A series of phenyl acetic acid and alpha-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00976-9

文献信息

• Novel thieno oxazine analogues as antihyperglycemic and lipid modulating agents
  作者：Saibal Kumar Das、K.Anantha Reddy、Chandrasekhar Abbineni、Javed Iqbal、J. Suresh、M. Premkumar、Ranjan Chakrabarti

  DOI：10.1016/s0960-894x(02)00976-9

  日期：2003.2

  A series of phenyl acetic acid and alpha-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.