methyl 8-(benzyloxycarbonylamino)-3-oxooctanoate | 152012-64-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 8-(benzyloxycarbonylamino)-3-oxooctanoate
• 英文别名: methyl 8-[N-(benzyloxycarbonyl)amino]-3-oxooctanoate；methyl 8-(N-Cbz-amino)-3-oxo-octanoate；methyl 3-oxo-8-(phenylmethoxycarbonylamino)octanoate
• CAS: 152012-64-1
• 化学式: C₁₇H₂₃NO₅
• 分子量: 321.373
• InChiKey: GTNBPGAENBXSTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 8-(benzyloxycarbonylamino)-3-oxooctanoate 在 氢氧化钾 、 sodium tetrahydroborate 、 偶氮二甲酸二苄酯 、 盐酸羟胺 、 三苯基膦 作用下， 以 甲醇 、 二氯甲烷 、 乙腈 为溶剂， 反应 95.0h， 生成 N-acetoxy-4-(1-(5-benzyloxycarbonylamino)pentyl)-2-azetidinone
  参考文献：
  名称：

  An Enantioselective Synthesis of Differentially Protected erythro-α,β-Diamino Acids and Its Application to the Synthesis of an Analogue of Rhodopeptin B5

  摘要：

  Methodology for the enantioselective synthesis of differentially protected erythro-alpha,beta-diamino acids from N-tosyloxy beta-lactams is reported. The requisite N-tosyloxy beta-lactams are readily available from simple beta-keto esters. The reported approach is flexible and compatible with a variety of functional groups. The synthetic utility of the method is demonstrated through its application to the preparation of an analogue of the antifungal cyclic peptide rhodopeptin B5.

  DOI：

  10.1021/jo016276m
• 作为产物：
  描述：

  N-苄氧羰基--6-氨基己酸 在 二丁基镁 作用下， 以 四氢呋喃 、 正庚烷 为溶剂， 反应 25.17h， 生成 methyl 8-(benzyloxycarbonylamino)-3-oxooctanoate
  参考文献：
  名称：

  An Enantioselective Synthesis of Differentially Protected erythro-α,β-Diamino Acids and Its Application to the Synthesis of an Analogue of Rhodopeptin B5

  摘要：

  Methodology for the enantioselective synthesis of differentially protected erythro-alpha,beta-diamino acids from N-tosyloxy beta-lactams is reported. The requisite N-tosyloxy beta-lactams are readily available from simple beta-keto esters. The reported approach is flexible and compatible with a variety of functional groups. The synthetic utility of the method is demonstrated through its application to the preparation of an analogue of the antifungal cyclic peptide rhodopeptin B5.

  DOI：

  10.1021/jo016276m

文献信息

• DUPLEX OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE
  申请人：Yamada Christina

  公开号：US20080085869A1

  公开（公告）日：2008-04-10

  Provided herein are duplex oligonucleotide complexes which can be administered to a cell, tissue or organism to silence a target gene without the aid of a transfection reagent(s). The duplex oligonucleotide complexes of the disclosure include a conjugate moiety that facilitates delivery to a cell, tissue or organism.

  本文提供了一种双链寡核苷酸复合物，可以被输送到细胞、组织或生物体中，以沉默目标基因，而无需转染试剂的帮助。本公开的双链寡核苷酸复合物包括一个共轭基团，有助于将其输送到细胞、组织或生物体中。
• Boronic acid containing oligonucleotides and polynucleotides
  申请人：Prolinx Incorporated

  公开号：US06013783A1

  公开（公告）日：2000-01-11

  The present invention relates to the field of nucleic acid immobilization, purification and detection and, more particularly, to boronic acid modified oligonucleotides and polynucleotides useful in bioconjugation reactions. The modified oligonucleotides and polynucleotides are useful in reactions for the immobilization and purification of macromolecules.

  本发明涉及核酸固定化、纯化和检测领域，更特别地，涉及硼酸修饰的寡核苷酸和多核苷酸，在生物偶联反应中有用。这些修饰的寡核苷酸和多核苷酸在大分子固定化和纯化反应中非常有用。
• Haptens, tracers, immunogens and antibodies for
  申请人：Abbott Laboratories

  公开号：US05424414A1

  公开（公告）日：1995-06-13

  Novel tethered hapten intermediates and related conjugates based on 3- phenyl-1-adamantaneacetic acid, as well as methods for making and using such conjugates. Haptens based on the above core structure may be substituted at any position on the phenyl ring, especially at the para position. Using tethered intermediates, immunogens, tracers, solid supports and labeled oligonucleotides are all described; as are methods for using the intermediates to prepare the conjugates, methods of using the conjugates to make and purify anitbodies, as assay tracers, and in nucleic acid hybridization assays. Kits containing haptenated oligonucleotides and anti-hapten conjugates are also described.

  基于3-苯基-1-金刚烷乙酸的小分子牵连半抗原中间体及相关结合物，以及制备和使用这些结合物的方法。基于上述核心结构的小分子半抗原可以在苯环上的任何位置进行取代，特别是在对位。使用牵连中间体，描述了免疫原、示踪剂、固定支持物和标记寡核苷酸等；同时还描述了使用中间体制备结合物的方法，使用结合物制备和纯化抗体的方法，以及在核酸杂交分析中作为检测剂的方法。还描述了包含半抗原化寡核苷酸和抗半抗原结合物的试剂盒。
• Haptens tracers, immunogens and antibodies for
  申请人：Abbott Laboratories

  公开号：US05616505A1

  公开（公告）日：1997-04-01

  Novel tethered hapten intermediates and related conjugates based on 3-phenyl-1-adamantaneacetic acid, as well as methods for making and using such conjugates. Haptens based on the above core structure may be substituted at any position on the phenyl ring, especially at the para position. Using tethered intermediates, immunogens, tracers, solid supports and labeled oligonucleotides are all described; as are methods for using the intermediates to prepare the conjugates, methods of using the conjugates to make and purify anitbodies, as assay tracers, and in nucleic acid hybridization assays. Kits containing haptenated oligonucleotides and anti-hapten conjugates are also described.

  基于3-苯基-1-金刚烷乙酸的小分子缀合物中间体及相关缀合物的新型系列，以及制备和使用这种缀合物的方法。基于上述核心结构的小分子缀合物可以在苯环上的任何位置被取代，尤其是在对位位置。使用缀合中间体，描述了免疫原、示踪剂、固相支持物和标记寡核苷酸；以及使用中间体制备缀合物的方法、使用缀合物制备和纯化抗体的方法、作为测定示踪剂和在核酸杂交测定中的方法。还描述了含有小分子缀合物的寡核苷酸和抗小分子缀合物的缀合物的试剂盒。
• TRIPARTITE OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE
  申请人：Yamada Christina

  公开号：US20100093085A1

  公开（公告）日：2010-04-15

  Provided herein are tripartite oligonucleotide complexes which can be administered to a cell, tissue or organism to silence a target gene. The tripartite oligonucleotide complexes of the disclosure may include a conjugate moiety that facilitates delivery to a cell, tissue or organism without the aid of a transfection reagent

  本文提供了三分体寡核苷酸复合物，可用于静默目标基因的细胞、组织或生物的治疗。本文所述的三分体寡核苷酸复合物可能包括一个共轭基团，以便在不需要转染试剂的情况下促进其递送到细胞、组织或生物中。