5-Hydroxy-octansaeure | 17369-50-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-Hydroxy-octansaeure
• 英文别名: 5-Hydroxyoctanoic acid
• CAS: 17369-50-5
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: LAWNVEFFZXVKAN-UHFFFAOYSA-N

物化性质

• 沸点：
  291.2±23.0 °C(Predicted)
• 密度：
  1.046±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-Hydroxy-octansaeure 在 硫酸 作用下， 反应 1.0h， 以86%的产率得到
  参考文献：
  名称：

  通过工程羰基还原酶立体选择性合成手性 δ-内酯

  摘要：

  来自粘质沙雷氏菌的羰基还原酶变体Sm CR M5是通过结构引导的定向进化获得的。该变体对 16 种测试底物中的大多数表现出改善的比活性 (U mg -1 )，并在 13 种 γ-/δ-内酯的不对称合成中提供高达 99% 的高立体选择性。特别是，SmCR M5对模型底物（即5-氧代癸酸）的比活性高出 13.8 倍，并在 99% ee 中产生 ( R )-δ-癸内酯，时空产率 (STY) 为 301 g L -1 d -1. 六种δ-内酯的高收率和高对映体纯度的制备表明这些高附加值化学品的生物催化合成是可行的，为贵金属催化提供了一种具有成本效益的绿色替代品。

  DOI：

  10.1039/d1cc04542c
• 作为产物：
  描述：

  methyl 5-oxooctanoate 生成 5-Hydroxy-octansaeure
  参考文献：
  名称：

  Lardelli,G. et al., Recueil des Travaux Chimiques des Pays-Bas, 1967, vol. 86, p. 481 - 503

  摘要：

  DOI：

文献信息

• [EN] DRUG CONJUGATES<br/>[FR] CONJUGUÉS DE MÉDICAMENT
  申请人：UNIV MISSOURI

  公开号：WO2009158633A1

  公开（公告）日：2009-12-30

  Conjugated compounds comprising a therapeutic or diagnostic agent linked to a substrate for a cell membrane transporter or receptor by lipophilic linker are provided.

  提供了包含治疗或诊断药物与细胞膜转运体或受体的底物通过亲脂性连接剂连接的共轭化合物。
• POLYURETHANES
  申请人：Ercole Francesca

  公开号：US20120252967A1

  公开（公告）日：2012-10-04

  The present invention relates to a polyurethane polymer comprising as part of its polymer backbone an α-oxy carbonyl moiety of general formula (I), where A and B represent the remainder of the polymer backbone and are the same or different, and R is an optionally substituted aliphatic hydrocarbon having three or more carbon atoms.

  本发明涉及一种聚氨酯聚合物，其聚合物主链中包含通式(I)的α-氧基羰基基团，其中A和B代表聚合物主链的其余部分，可以相同也可以不同，R是具有三个或三个以上碳原子的可选择取代的脂肪族碳氢化合物。
• REUSABLE PRINT MEDIUM AND METHOD OF MANUFACTURING THEREOF
  申请人：OCE TECHNOLOGIES B.V.

  公开号：US20130137805A1

  公开（公告）日：2013-05-30

  The present invention relates to a reusable print medium comprising a substrate and a sacrificial layer. The sacrificial layer contains a hotmelt composition at least comprising an amorphous material. The amorphous material is a resin being a reaction product of a first monomer A, said first monomer A being a polyhydroxyl alcohol comprising X hydroxyl functional groups, wherein X≧2, monomer A optionally comprises a primary or secondary amine functionality; a second monomer B, being an aromatic monocarboxylic acid; a third monomer C, said third monomer C being able to form an ester linkage with an alcohol and/or an amide linkage with a primary or secondary amine; and optionally, a fourth monomer D, being an aromatic monocarboxylic acid different from the second monomer B. The sacrificial layer including the printed image may be removed from the substrate by applying heat. A new sacrificial layer may be applied such that the reusable print medium is ready to be reused. The present invention also relates to a method of manufacturing a reusable print medium according to the present invention, a method of printing and recycling such a print medium and an apparatus for printing and recycling such a print medium.

  本发明涉及一种可重复使用的印刷介质，包括基底和牺牲层。牺牲层含有至少包括非晶态材料的热熔组合物。该非晶态材料是一种树脂，是第一单体A的反应产物，第一单体A是一种聚羟基醇，包括X个羟基官能团，其中X≥2，单体A可选包括一种主链或侧链氨基官能团；第二单体B是一种芳香单羧酸；第三单体C能够与醇形成酯键和/或与一种主链或侧链氨基形成酰胺键；可选地，第四单体D是一种与第二单体B不同的芳香单羧酸。可以通过施加热量从基底中去除包括印刷图像的牺牲层。可以应用新的牺牲层，使可重复使用的印刷介质准备好被重用。本发明还涉及一种制造可重复使用的印刷介质的方法，一种印刷和回收这样的印刷介质的方法，以及一种印刷和回收这样的印刷介质的装置。
• Photosensitive composition
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0312624A1

  公开（公告）日：1989-04-26

  The present invention relates to a photosensitive composition containing at least one compound selected from the group consisting of N-acyl amino acid derivatives, hydroxycarboxylic acids and their derivatives, condensates of an aliphatic or aromatic aldehyde with a polyhydric alcohol, acylated polysaccharides and metallic soaps. From the photosensitive composition of the present invention, moldings having excellent shape retentivity and/or compatibility of the components thereof with one another can be produced. Therefore, the production of moldings from a composition which has been heretofore impossible is made possible. Particularly a composition having a good moldability during the molding operation can be employed. The composition is useful for the preparation of printing plate materials having a good developability and printing plates, particularly flexible printing plates and flexographic printing plates, having an improved ink solvent resistance.

  本发明涉及一种光敏组合物，该组合物含有至少一种选自 N-酰基氨基酸衍生物、羟基羧酸及其衍生物、脂肪醛或芳香醛与多元醇的缩合物、酰化多糖和金属皂的化合物。利用本发明的光敏组合物，可以生产出具有极佳形状保持性和/或其各组分之间相容性的模塑件。因此，利用本发明的组合物生产模塑件成为可能，而这在以前是不可能的。特别是可以使用在成型操作过程中具有良好成型性的组合物。该组合物可用于制备显影性良好的印版材料和耐油墨溶剂性更好的印版，特别是柔性印版和柔性版印刷印版。
• Process for the preparation of lactic acid polyesters
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0603889A2

  公开（公告）日：1994-06-29

  [Construction] In a preparation process of a polyhydroxycarboxylic acid comprising carrying out dehydration polycondensation of hydroxycarboxylic acids which contain at least lactic acid in an organic solvent in the presence or in the absence of a catalyst a preparation process of the polyhydroxycarboxylic acid comprising use of a raw material containing ethyllactate of which amount is 0.3 mole % or less to a reduced mole number of the raw material monomer. [Effect] A high molecular weight of polyhydroxycarboxylic acid is obtained with ease and with inexpensive industrially by a direct polycondensation of a hydroxycarboxylic acid which contains at least lactic acid.

  施工 在聚羟基羧酸的制备工艺中，包括在有机溶剂中，在有催化剂存在或无催化剂存在的情况下，对至少含有乳酸的羟基羧酸进行脱水缩聚，聚羟基羧酸的制备工艺包括使用含有乙内酯的原料，乙内酯的量占原料单体减少摩尔数的 0.3 摩尔%或更少。 效果 通过直接缩聚至少含有乳酸的羟基羧酸，可以方便地获得高分子量的聚羟基羧酸，而且工业成本低廉。