N-hexadecylpyrene-1-sulfonamide | 351002-71-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: N-hexadecylpyrene-1-sulfonamide
• CAS: 351002-71-6
• 化学式: C₃₂H₄₃NO₂S
• 分子量: 505.765
• InChiKey: FAXRWJMTLJBKAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.7
• 重原子数：
  36
• 可旋转键数：
  17
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4,6-三(4-吡啶)1,3,5-三嗪 、 [Ru₂(p-cymene)₂(2,5-dioxido-1,4-benzoquinonato)Cl₂] 、 N-hexadecylpyrene-1-sulfonamide 、 silver trifluoromethanesulfonate 以 甲醇 为溶剂， 以65%的产率得到[(N-hexadecylpyrene-1-sulfonamide)*Ru6(p-cymene)6(2,4,6-tris(pyridin-4-yl)-1,3,5-triazine)2(O2C6H2O2)3](triflate)6
  参考文献：
  名称：

  Drug delivery of lipophilic pyrenyl derivatives by encapsulation in a water soluble metalla-cage

  摘要：

  在功能化的芘衍生物（pyrene–R）的存在下，2,4,6-三（吡啶-4-基）-1,3,5-三嗪（tpt）三角形面板与对伞花烃（p-PriC6H4Me）钌建筑块和2,5-二氧-1,4-苯醌酸（dobq）桥自组装，形成了三角棱柱宿主-客体化合物[(pyrene–R) ⊂ Ru6(p-PriC6H4Me)6(tpt)2(dobq)3]6+（[(pyrene–R) ⊂ 1]6+）。已经成功地纳入了八种单取代的芘衍生物，其中包括生物相关的结构（a = 1-芘丁酸，b = 1-芘丁醇，c = 1-芘甲胺，d = 1-芘甲丁酸酯，e = 1-（4,6-二氯-1,3,5-三嗪-2-基）芘，f = N-十六烷基芘-1-磺酰胺，g = 芘依他尼酸胺，h = 2-（芘-1-基甲氨酰基）苯乙酸酯），以及一种双取代的芘衍生物（i = 1,8-双（3-甲基-丁炔-1-基-3-醇）芘）。通过NMR（1H，2D，DOSY）光谱和电喷雾电离质谱（ESI-MS）证实了这些系统的笼状性质，芘基团牢固地封装在笼的疏水腔内，功能基团指向外部。这些水溶性化合物的细胞毒性已经使用人卵巢A2780癌细胞进行了确定。所有的宿主-客体系统的细胞毒性都比空笼本身[1][CF3SO3]6（IC50 = 23 μM）更强，其中最活跃的笼状化合物[f ⊂ 1][CF3SO3]6的细胞毒性高出一个数量级。

  DOI：

  10.1039/c0dt00436g

文献信息

• RADIATION DOSIMETRY SOL OR GEL AND RADIATION DOSIMETER COMPRISING SAME AS MATERIAL FOR RADIATION DOSIMETRY
  申请人：Riken

  公开号：EP3686632A1

  公开（公告）日：2020-07-29

  There is provided a radiation dosimetry sol or gel, and a radiation dosimeter containing the sol or the gel as a material for radiation dosimetry. A radiation dosimetry sol or gel characterized by comprising a compound (A) having an excitation light-induced fluorescence property that is changed by a radiolysis product of water; and a silicate salt (B). A radiation dosimetry sol or gel characterized by comprising a compound (A) having an excitation light-induced fluorescence property that is changed by a radiolysis product of water; a silicate salt (B); a water-soluble organic polymer (C) having an organic acid salt structure or an organic acid anion structure; and a dispersant (D) for the silicate salt (B). A radiation dosimeter comprising, as a material for radiation dosimetry, the above-mentioned radiation dosimetry sol or gel.

  提供了一种辐射剂量测定溶胶或凝胶，以及一种含有该溶胶或凝胶作为辐射剂量测定材料的辐射剂量计。 一种辐射剂量测定溶胶或凝胶，其特征在于包含一种化合物 (A)，该化合物具有由水的辐射分解产物改变的激发光诱导荧光特性；以及一种硅酸盐 (B)。 一种辐射剂量计溶胶或凝胶，其特征在于包含一种化合物（A），该化合物具有受水的辐射分解产物影响而改变的激发光诱导荧光特性；一种硅酸盐（B）；一种具有有机酸盐结构或有机酸阴离子结构的水溶性有机聚合物（C）；以及一种用于硅酸盐（B）的分散剂（D）。 一种辐射剂量计，包括作为辐射剂量测定材料的上述辐射剂量测定溶胶或凝胶。
• Radiation dosimetry sol or gel and radiation dosimeter comprising same as material for radiation dosimetry
  申请人：RIKEN

  公开号：US11150358B2

  公开（公告）日：2021-10-19

  A radiation dosimetry sol or gel, and a radiation dosimeter containing the sol or the gel as a material for radiation dosimetry. A radiation dosimetry sol or gel including a compound (A) having an excitation light-induced fluorescence property that is changed by a radiolysis product of water; and a silicate salt (B). A radiation dosimetry sol or gel including a compound (A) having an excitation light-induced fluorescence property that is changed by a radiolysis product of water; a silicate salt (B); a water-soluble organic polymer (C) having an organic acid salt structure or an organic acid anion structure; and a dispersant (D) for the silicate salt (B). A radiation dosimeter including, as a material for radiation dosimetry, the above-mentioned radiation dosimetry sol or gel.

  一种辐射剂量测定溶胶或凝胶，以及一种含有该溶胶或凝胶作为辐射剂量测定材料的辐射剂量计。一种辐射剂量测定溶胶或凝胶，包括一种化合物 (A)，其激发光诱导荧光特性会因水的辐射分解产物而改变；以及一种硅酸盐 (B)。一种辐射剂量测定溶胶或凝胶，包括一种化合物（A），其激发光诱导荧光特性会因水的辐射分解产物而改变；一种硅酸盐（B）；一种水溶性有机聚合物（C），其具有有机酸盐结构或有机酸阴离子结构；以及一种用于硅酸盐（B）的分散剂（D）。一种辐射剂量计，包括作为辐射剂量测定材料的上述辐射剂量测定溶胶或凝胶。
• SELF INDICATING RADIATION ALERT DOSIMETER
  申请人：Patel Gordhabhai N.

  公开号：US20120205591A1

  公开（公告）日：2012-08-16

  Described is a self-indicating instant radiation dosimeter ( 1001 ) for monitoring high energy radiations, such as X-ray. The dosimeter contains a radiation sensitive, color changing, indicating composition ( 10 ), e.g., a diacetylene (R—C≡C—C≡C—R′, where R and R′ are substituents groups) or a radiochromic dye, a polymeric binder ( 20 ) and optionally a shelf life extender ( 50 ) or an activator ( 40 ). The radiation sensitive composition ( 10 ) changes color instantly when exposed to high energy radiation. The dose is estimated by comparing the color with a color reference chart or more accurately with a spectrophotometer or an optical densitometer. The radiation sensitive composition ( 10 ) is protected from low energy radiation such as UV light, by a layer of low energy absorbing materials, such as UV absorbers.
• INNOVATION TO ASSAY MIXING
  申请人：Bio-Rad Laboratories, Inc.

  公开号：US20150090343A1

  公开（公告）日：2015-04-02

  Methods, articles of manufacture, and kits for calibrating fluid delivery systems are provided. A fluid delivery system connected to N input streams, where N is an integer greater than or equal to 2, mixes together fluid from the N input streams to form an output stream. The methods involve obtaining N test solutions, each containing a dye, providing optical absorbances of the test solutions at appropriate wavelengths, injecting the test solutions into the input streams, mixing the test solutions, and measuring the absorbance of the output stream at the same wavelengths. The methods also involve comparing the absorbances of the test solutions with the absorbances of the output stream, which can include calculating ratios and comparing the ratios with target values. The methods can further involve adjusting operation of the fluid delivery system based upon the absorbances. In some embodiments, the dyes have largely non-overlapping absorbance spectra.
• US9766213B2
  申请人：——

  公开号：US9766213B2

  公开（公告）日：2017-09-19