氧代赖氨酸 | 15219-97-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 氧代赖氨酸
• 中文别名: L-氧代赖氨酸
• 英文名称: L-4-Oxalysine
• 英文别名: O-(2-Aminoethyl)-L-serine；(2S)-2-amino-3-(2-aminoethoxy)propanoic acid
• CAS: 15219-97-3
• 化学式: C₅H₁₂N₂O₃
• 分子量: 148.162
• InChiKey: SLTGLTLBIVDQKE-BYPYZUCNSA-N

物化性质

• 沸点：
  268.75°C (rough estimate)
• 密度：
  1.2809 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  98.6
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2922509090

反应信息

• 作为反应物：
  描述：

  氧代赖氨酸 在 腺嘌呤黄素 、 catalase Pseudomonas putida N-methyl-L-amino acid dehydrogenase 、 T_. viride L-lysine oxidase 、 Tris buffer 作用下， 以 various solvent(s) 为溶剂， 反应 72.0h， 生成 (S)-3-羧基吗啉
  参考文献：
  名称：

  Enzymatic synthesis of cyclic amino acids by N-methyl-l-amino acid dehydrogenase from Pseudomonas putida

  摘要：

  A new enzymatic system for the synthesis of enantiomerically pure cyclic amino acids (CAA) from the corresponding diamino acids or racemic CAA is described. alpha,omega-Diamino acids were oxidized to alpha-keto acids with amino acid oxidases (AAO). The alpha-keto acids were spontaneously transformed into cyclic imino acids in the reaction medium. The resulting imines were reduced to the L-form CAA with N-methyl-L-amino acid dehydrogenase (NMAADH) from Pseudomonas putida ATCC12633 using NADPH as a cofactor. L-Form CAA were also obtained from racemic CAA using D-amino-acid oxidase and NMAADH. Using this method, a new compound [1,4]thiazepane-3-carboxylic acid (Fig. 1) was synthesized from aminopropylcystein. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetasy.2006.07.005

文献信息

• Enzymatic synthesis of cyclic amino acids by N-methyl-l-amino acid dehydrogenase from Pseudomonas putida
  作者：Mari Yasuda、Makoto Ueda、Hisashi Muramatsu、Hisaaki Mihara、Nobuyoshi Esaki

  DOI：10.1016/j.tetasy.2006.07.005

  日期：2006.7

  A new enzymatic system for the synthesis of enantiomerically pure cyclic amino acids (CAA) from the corresponding diamino acids or racemic CAA is described. alpha,omega-Diamino acids were oxidized to alpha-keto acids with amino acid oxidases (AAO). The alpha-keto acids were spontaneously transformed into cyclic imino acids in the reaction medium. The resulting imines were reduced to the L-form CAA with N-methyl-L-amino acid dehydrogenase (NMAADH) from Pseudomonas putida ATCC12633 using NADPH as a cofactor. L-Form CAA were also obtained from racemic CAA using D-amino-acid oxidase and NMAADH. Using this method, a new compound [1,4]thiazepane-3-carboxylic acid (Fig. 1) was synthesized from aminopropylcystein. (c) 2006 Published by Elsevier Ltd.