Hammett Correlation of Nornicotine Analogues in the Aqueous Aldol Reaction: Implications for Green Organocatalysis
摘要:
A series of meta- and para-substituted 2-arylpyrrolidines were synthesized and examined for their ability to catalyze an aqueous aldol reaction under buffered conditions. Kinetic analysis of arylpyrrolidine-catalyzed reactions displayed a linear Hammett correlation with rho = 1.14 (R-2 = 0.996), indicating that the reaction is accelerated by electron-withdrawing aryl rings. These results show promise for the development of a synthetically viable aqueous organo-catalyst.
Electron-transfer-induced photochemical reactions of (silylallyl)iminium and benzylpyrrolinium salts by dual diradical and diradical cation cyclization pathways
作者:In Seop Cho、Chung Lan Tu、Patrick S. Mariano
DOI:10.1021/ja00165a052
日期:1990.4
The electron-transfer-induced photocyclization reactions of a series of N- and C-silylmethallyl-substituted iminium and 1-benzyl-1-pyrrolinium salts have been investigated in order to gain information about their mechanistic course and to probe their synthetic potential. The results obtained from these studies demonstrate that diradical cation intermediates formed in these processes can be transformed
OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES