1-acetyl-5-(2-methoxyphenyl)-3-(5-chloro-thienyl)-2-pyrazoline | 152432-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-acetyl-5-(2-methoxyphenyl)-3-(5-chloro-thienyl)-2-pyrazoline
• 英文别名: 1-[5-(5-Chlorothiophen-2-yl)-3-(2-methoxyphenyl)-3,4-dihydropyrazol-2-yl]ethanone
• CAS: 152432-20-7
• 化学式: C₁₆H₁₅ClN₂O₂S
• 分子量: 334.826
• InChiKey: IIPOCTQCHAJGBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  70.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-acetyl-5-(2-methoxyphenyl)-3-(5-chloro-thienyl)-2-pyrazoline 、 copper dichloride 以 乙醇 为溶剂， 以80%的产率得到copper(II) di-1-acetyl-5-(2-methoxyphenyl)-3-(5-chlorothienyl)-2-pyrazoline dichloro
  参考文献：
  名称：

  Dudeja, Mamta; Malhotra, Rajesh; Gupta, Mohinder Paul, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1993, vol. 32, # 11, p. 975 - 979

  摘要：

  DOI：
• 作为产物：
  描述：

  邻甲氧基苯甲醛 在 sodium hydroxide 、 肼 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 1-acetyl-5-(2-methoxyphenyl)-3-(5-chloro-thienyl)-2-pyrazoline
  参考文献：
  名称：

  Dudeja, Mamta; Malhotra, Rajesh; Gupta, Mohinder Paul, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1993, vol. 32, # 11, p. 975 - 979

  摘要：

  DOI：

文献信息

• Ligational Behaviour of Substituted 4,5-Dihydropyrazoles Towards Oxovanadium(IV) and Metalation Effect on the Antimicrobial Activity
  作者：Mamta Dudeja、Rajesh Malhotra、Mohinder PaulGupta、Kuldip SinghDhindsa

  DOI：10.1080/00945719608004344

  日期：1996.7

  Complexes of 1-acetyl-5-aryl-3-(substituted thienyl)-4,5-dihydropyrazoles [AATP; Ar = 2-OCH3, 4-OCH3 and 3,4-(OCH3)(2)] with oxovanadium(IV) ion have been synthesized and characterized on the basis of elemental analyses, molar conductance, magnetic susceptibility, molecular weight determination and spectral (ESR, IR and UV) data. The pyrazoles behaved as bidentate ligands coordinating through oxygen and nitrogen N(2) of the carbonyl and azomethine groups, respectively. ESR data of the powdered samples of the complexes and in DMF solution suggested a distorted octahedral environment around oxovanadium(IV). The ligands and vanadyl complexes were evaluated for antifungal activity against Colletotrichum capsicum and Rhizoctonia solani at 37 degrees C and antibacterial activity against Bacillus subtilis and Escherichia coli at 28 degrees C. Metalation had pronounced effects on the antimicrobial activity of the ligands.
• Dudeja, Mamta; Malhotra, Rajesh; Gupta, Mohinder Paul, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1993, vol. 32, # 11, p. 975 - 979
  作者：Dudeja, Mamta、Malhotra, Rajesh、Gupta, Mohinder Paul、Dhindsa, Kuldip Singh

  DOI：——

  日期：——