12-acetoxy-dodecanoic acid methyl ester | 101083-38-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 12-acetoxy-dodecanoic acid methyl ester
• 英文别名: Acetylsabinsaeure-methylester；ω-Acetoxy-laurinsaeure-methylester；12-Acetoxy-dodecansaeure-methylester；Methyl 12-acetyloxydodecanoate
• CAS: 101083-38-9
• 化学式: C₁₅H₂₈O₄
• 分子量: 272.385
• InChiKey: QCUNKXVEONHZSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  12-acetoxy-dodecanoic acid methyl ester 在 [t-Bu₂SnOH(Cl)]2 作用下， 以 甲醇 为溶剂， 反应 16.5h， 以100%的产率得到methyl 12-hydroxydodecanoate
  参考文献：
  名称：

  Orita, Akihiro; Sakamoto, Katsumasa; Hamada, Yuuki, Synlett, 2000, # 1, p. 140 - 142

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 12-hydroxydodecanoate 、 乙酰氯 在 吡啶 作用下， 生成 12-acetoxy-dodecanoic acid methyl ester
  参考文献：
  名称：

  Chuit; Hausser, Helvetica Chimica Acta, 1929, vol. 12, p. 478

  摘要：

  DOI：

文献信息

• Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes
  申请人：McDaniel C. Steven

  公开号：US20100210745A1

  公开（公告）日：2010-08-19

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peotide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文公开了一些聚合材料，如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；一种表面处理，如纺织品涂层或蜡；一种填料，用于这样的聚合材料或表面处理，其中包括一种酶，如酯酶（例如，脂肪水解酶，硫酸酯水解酶，有机磷化合物降解酶），降解细胞壁和/或细胞膜成分的酶（例如，溶菌酶，裂解转糖基酶），生物杀菌或生物静态肽，以及/或肽酶。本文还公开了通过将酶纳入可通过脂肪水解酶、水解酶和/或脲酶的活性交联材料中来改变材料性能，如使用寿命、柔韧性或刚度的方法。
• Anti-fouling Paints and Coatings
  申请人：Reactive Surfaces LTD

  公开号：US20150191607A1

  公开（公告）日：2015-07-09

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peptide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文披露了聚合材料，例如涂层、塑料、层压材料、复合材料、弹性体、粘合剂或密封剂；表面处理，例如纺织品整理或蜡；填充剂，用于这种聚合材料或表面处理，包括酯酶（例如脂肪水解酶、硫酸酯水解酶、有机磷化合物降解酶）的酶，降解细胞壁和/或细胞膜成分的酶（例如溶菌酶、裂解转葡糖苷酶），生物杀菌或生物稳定肽，和/或肽酶。本文还披露了通过将酶并入能够通过脂肪水解酶、水解酶和/或脲酶的活性进行化学交联的材料中，改变材料性能（例如使用寿命、柔韧性或刚度）的方法。
• Orita, Akihiro; Sakamoto, Katsumasa; Hamada, Yuuki, Synlett, 2000, # 1, p. 140 - 142
  作者：Orita, Akihiro、Sakamoto, Katsumasa、Hamada, Yuuki、Otera, Junzo

  DOI：——

  日期：——
• Highly Efficient Deacetylation by Use of the Neutral Organotin Catalyst [tBu2SnOH(Cl)]2
  作者：Akihiro Orita、Yuuki Hamada、Takehiko Nakano、Shinji Toyoshima、Junzo Otera

  DOI：10.1002/1521-3765(20010803)7:15<3321::aid-chem3321>3.0.co;2-h

  日期：2001.8.3

  Deprotection of acetyl esters is effected cleanly by the neutral organotin catalyst, [tBu(2)SnOH(Cl)](2). The mildness of the reaction gives rise to great synthetic versatility and in the process a variety of functional groups are tolerated. Differentiations between primary, secondary, and tertiary alcohols and between acetyl ester and other esters are feasible. No racemization occurs with chiral acetyl esters. Exclusive deprotection of primary acetyl esters in carbohydrates and nucleosides is observed. The crude product thus obtained can be used for further reactions without purification.
• Chuit; Hausser, Helvetica Chimica Acta, 1929, vol. 12, p. 478
  作者：Chuit、Hausser

  DOI：——

  日期：——