5-(Propan-2-yl)oxolan-2-ol | 89079-90-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 5-(Propan-2-yl)oxolan-2-ol
• 英文别名: 5-propan-2-yloxolan-2-ol
• CAS: 89079-90-3
• 化学式: C₇H₁₄O₂
• 分子量: 130.187
• InChiKey: UMZQIMQQHUXUPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-allyl-N-methyl-(bisdimethylamino) phosphoramide 、 异丁醛 在 正丁基锂 作用下， 生成 5-(Propan-2-yl)oxolan-2-ol
  参考文献：
  名称：

  等价阴离子同烯异氰酸酯issus d'enephosphoramides：反应AVEC LA二苯甲酮

  摘要：

  α-磷酰胺基锂取代的烯丙基碳负离子与二苯甲酮一起用作均烯酸酯试剂，可选择性地产生α-或γ-羟烷基化产物。用镁取代锂几乎完全导致γ取代。加合物的酸性水解是制备γ-乳糖醇的新途径。

  DOI：

  10.1016/s0022-328x(00)99263-5

文献信息

• COUTROT, PH.;DORMOY, J. R.;MOUKIMOU, A., J. ORGANOMET. CHEM., 1983, 258, N 2, C25-C28
  作者：COUTROT, PH.、DORMOY, J. R.、MOUKIMOU, A.

  DOI：——

  日期：——
• [EN] COMPOUNDS USEFUL FOR TREATING LIVER DISEASES<br/>[FR] COMPOSÉS UTILES POUR LE TRAITEMENT DES MALADIES DU FOIE
  申请人：ABIONYX PHARMA SA

  公开号：WO2021059023A1

  公开（公告）日：2021-04-01

  This invention provides compounds of Formulae (A) and (B) and pharmaceutically acceptable salts, solvates, esters, amides, and prodrugs thereof, including 2-(4-(3-hydroxy-3- (4-(methylthio)phenyl)prop-1-en-1-yl)-2,6-dimethylphenoxy)-2-methylpropanoic acid ("Compound I"), 3-(4-((1-hydroxy-2-methylpropan-2-yl)oxy)-3,5-dimethylphenyl)-1-(4- (methylthio)phenyl)prop-2-en-1-one ("Compound II") and 3-(4-((1-hydroxy-2-methylpropan-2- yl)oxy)-3,5-dimethylphenyl)-1-(4-(methylthio)phenyl)prop-2-en-1-ol ("Compound III"), and pharmaceutically acceptable salts, solvates, esters, amides, and prodrugs thereof. The invention further provides pharmaceutical compositions comprising a compound of Formulae (A) and (B) or a pharmaceutically acceptable salt, solvate, ester, amide, or prodrug thereof, including Compound I, Compound II, or Compound III, or a pharmaceutically acceptable salt, solvate, ester, amide, or prodrug thereof, and a pharmaceutically acceptable carrier or vehicle. The compounds and compositions disclosed herein are useful for treating or preventing liver disease such as liver fibrosis, fatty liver disease, non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).
• Equivalents anioniques homoenolates issus d'enephosphoramides: reaction avec la benzophenone
  作者：Ph. Coutrot、J.R. Dormoy、A. Moukimou

  DOI：10.1016/s0022-328x(00)99263-5

  日期：1983.11

  α-Phosphoramidolithium substituted allylic carbanions are used as homoenolate reagents with benzophenone and give regioselectively α- or γ-hydroxyalkylation products. Replacement of lithium by magnesium leads to γ substitution almost exclusively. Acidic hydrolysis of the adducts is a novel route to γ-lactol.

  α-磷酰胺基锂取代的烯丙基碳负离子与二苯甲酮一起用作均烯酸酯试剂，可选择性地产生α-或γ-羟烷基化产物。用镁取代锂几乎完全导致γ取代。加合物的酸性水解是制备γ-乳糖醇的新途径。