di(2-chlorobenzyl) sulfone | 756527-91-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: di(2-chlorobenzyl) sulfone
• 英文别名: bis-(2-chloro-benzyl)-sulfone；Bis-(2-chlor-benzyl)-sulfon；Bis(2-chlorobenzyl) sulfone；1-chloro-2-[(2-chlorophenyl)methylsulfonylmethyl]benzene
• CAS: 756527-91-0
• 化学式: C₁₄H₁₂Cl₂O₂S
• 分子量: 315.22
• InChiKey: BLMRLVYMSLUQRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  di(2-chlorobenzyl) sulfone 在 乙醇 、 sodium ethanolate 、 草酸二乙酯 作用下， 生成 3,4-bis-benzoyloxy-2,5-bis-(2-chloro-phenyl)-thiophene-1,1-dioxide
  参考文献：
  名称：

  Cyclic Sulfones.¹ Preparation of 2,5-Di-(halophenyl)-3,4-dihydroxythiophene-1-dioxides

  摘要：

  DOI：

  10.1021/ja01105a016
• 作为产物：
  描述：

  邻氯氯苄 在 sodium dithionite 、 1-butyl-3-methylimidazolium Tetrafluoroborate 作用下， 反应 6.0h， 以57%的产率得到di(2-chlorobenzyl) sulfone
  参考文献：
  名称：

  A Simple and Efficient Direct Method for the Synthesis of Symmetric Dibenzyl Sulfones from Sodium Dithionite and Benzyl Chlorides in Ionic Liquid

  摘要：

  Symmetric dibenzyl sulfones were synthesized in ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF4) at 100 degrees C from various benzyl chlorides and sodium dithionite in moderate yields.

  DOI：

  10.1007/s00706-006-0530-0

文献信息

• (E)-4-carboxystyrl-4-chlorobenzyl sulfone and pharmaceutical compositions thereof
  申请人：——

  公开号：US20030149109A1

  公开（公告）日：2003-08-07

  Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.

  使用α,β-不饱和芳基磺酮进行预处理可以保护正常细胞免受两类抗癌化疗药物的细胞毒副作用。在患者进行含细胞周期有丝分裂期抑制剂或拓扑异构酶抑制剂的抗癌化疗之前，给予一种细胞保护性磺酮化合物，可以减少或消除抗癌药物对正常细胞的细胞毒副作用。α,β-不饱和芳基磺酮的细胞保护作用使得临床医生可以安全地增加抗癌化疗药物的剂量。
• Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
  申请人：——

  公开号：US20040214903A1

  公开（公告）日：2004-10-28

  Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.

  预处理使用α，β不饱和芳基磺酮可以保护正常细胞免受两类抗癌化疗药物的细胞毒副作用。在使用有丝分裂期细胞周期抑制剂或拓扑异构酶抑制剂的抗癌化疗前向患者给予细胞保护性磺酮化合物，可以减少或消除抗癌药物对正常细胞的细胞毒副作用。α，β不饱和芳基磺酮的细胞保护作用使临床医生可以安全地增加抗癌化疗药物的剂量。
• Formulations of radioprotective alpha, beta unsaturated aryl sulfones
  申请人：Onconova Therapeutics, Inc.

  公开号：EP2769719A1

  公开（公告）日：2014-08-27

  Solution and suspension formulations are provided for administration prior to or after exposure to ionizing radiation for reducing toxic effects of the radiation in a subject which comprises an effective amount of at least one radioprotective α, β unsaturated aryl sulfone wherein the composition has a pH within the range of about 8 to about 9.

  本发明提供了溶液和悬浮液制剂，用于在电离辐射照射前或照射后给药，以减少辐射对受试者的毒性影响，该制剂包含有效量的至少一种辐射保护性 α、β 不饱和芳基砜，其中组合物的 pH 值在约 8 到约 9 的范围内。
• Radioprotection, radiomitigation and radiorecovery
  申请人：Paxton-Pierson Suzanne J

  公开号：US10946075B1

  公开（公告）日：2021-03-16

  Radioprotection, Radiomitigation and Radiorecovery: Timed use of more widely available antiradiation agents in a kit for subjects affected by ionizing radiation, radiomimetic exposure and radiocontamination. The method in the form of strategically timed preemptive and postirradiation compositions; radioprotection, radiomitigation and radiorecovery formulations are comprised of various available anticorporation, antioxidant, decorporation, multi-mechanistic, pro-survival, pro-hematopoietic, anti-fibrotic and other novel ingredients in synergistic mixtures to be used in critically-timed manners. Radioprotection, radiomitigation and radiorecovery of a mammal prior to, during, just after or well-after exposure to ionizing radiation energy—alpha, beta, neutron, gamma, X-ray and damaging radiofrequency radiation—for long or short periods of time, and exposure to or contamination by radioactive elements or compounds such as radioiodine, radiostrontium, radiophosphorus, radiocobalt, radiocadmium, radiopollonium, radioradium, radiocesium, radiouranium, radioamericium, radiopollonium, radiocerium, radioindium, and the like. Radiomimeticprotective method for mucosal exposure is also described.

  辐射防护、辐射缓解和辐射恢复：针对受电离辐射、仿辐射照射和辐射污染影响的受试者，在成套药剂中适时使用更广泛使用的抗辐射剂。该方法采用战略定时的辐射前和辐射后组合物形式；辐射防护、辐射缓解和辐射恢复制剂由各种可用的抗穿孔、抗氧化、装饰穿孔、多机制、促生存、促造血、抗纤维化和其他新型成分组成，以协同混合物的形式在关键时间使用。在哺乳动物长期或短期暴露于电离辐射能量--α、β、中子、γ、X 射线和破坏性射频辐射之前、期间、刚暴露之后或暴露之后，对其进行辐射防护、辐射缓解和辐射恢复、放射性碘、放射性锶、放射性磷、放射性钴、放射性镉、放射性钋、放射性钒、放射性铯、放射性钛、放射性镅、放射性钋、放射性铈、放射性铟等放射性元素或化合物的照射或污染。此外，还介绍了用于粘膜照射的仿辐射保护方法。
• 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES CONTAINING AN ARGININE MIMIC AS ENZYME INHIBITORS
  申请人：CORVAS INTERNATIONAL, INC.

  公开号：EP0765339B1

  公开（公告）日：1999-01-27