11-Keto-triacontansaeure | 58429-89-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 11-Keto-triacontansaeure
• 英文别名: 11-Oxo-triacontanoesaeure；11-oxo-triacontanoic acid；11-Oxo-triacontansaeure；11-Oxotriacontanoic acid
• CAS: 58429-89-3
• 化学式: C₃₀H₅₈O₃
• 分子量: 466.789
• InChiKey: HZSPEMFCEKPTSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.5
• 重原子数：
  33
• 可旋转键数：
  28
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  11-Keto-triacontansaeure 生成 三十烷酸
  参考文献：
  名称：

  Mahato; Sahu; Narayanaswami, Journal of the Indian Chemical Society, 1975, vol. 52, # 7, p. 626 - 628

  摘要：

  DOI：
• 作为产物：
  描述：

  11-Keto-triacontansaeure-methylester 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成 11-Keto-triacontansaeure
  参考文献：
  名称：

  Mahato; Sahu; Narayanaswami, Journal of the Indian Chemical Society, 1975, vol. 52, # 7, p. 626 - 628

  摘要：

  DOI：

文献信息

• Herbal composition for treating various disorders including psoriasis, a process for preparation thereof and method for treatment of such disorders
  申请人：LUPIN LIMITED

  公开号：US20030194456A1

  公开（公告）日：2003-10-16

  The invention provides a novel herbal composition containing the extracts of the leaves and/or stem of Argemone mexicana plant, optionally containing the extracts of the fruits of Cuminum cyminum , which exhibits useful in vitro, in vivo and interesting immunological and pharmacological activities; a process for preparation thereof; and a method of treatment of psoriasis and related immunological and biological disorders by administration of the said novel herbal composition. The useful in vitro, in vivo and interesting immunological and pharmacological activities exhibited by the extracts and fractions of the leaves and/or stem of Argemone mexicana plant include immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFNgamma inhibition, IL-10 induction, keratinocyte proliferation inhibition, keratolytic activity, endothelial cell proliferation inhibition, inhibition of cell adhesion molecule expression such as ICAM-1, MEST inhibition, and enzymes inhibition such as p60src Tyrosine kinase, which are known to be involved in anti-psoriatic activity. The novel herbal composition(s) is useful in the treatment of various disorders, such as psoriasis including plaque psoriasis, gutatte psoriasis, pustular psoriasis and psoriasis of the nails; dermatitis and scleroderma; eczema; inflammatory disorders and other autoimmune diseases like psoriatic arthritis, rheumatoid arthritis, Crohn's disease, multiple sclerosis, irritable bowel disease, ankylosing spondilitis, systemic lupus erythremetosus and Sjogren's syndrome; allergies like asthma and chronic obstructive pulmonary disease and is safe, well-tolerated, non-toxic, with minimal and reversible adverse reactions or side effects, and most importantly, with minimal relapse or recurrence of the disease following completion of a treatment regimen. The invention also describes the presence of phosphodiesterase (III, IV and V) inhibition and 5-Lipoxygenase inhibition in the aqueous, ethanolic or aqueous-ethanolic extracts of fruits of Cuminum cyminum plant.

  本发明提供了一种新型草药组合物，其中含有以下植物的叶子和/或茎的提取物 Argemone mexicana 植物的叶和/或茎的提取物，可选择含有 孜然 本发明提供了一种新型草药组合物，该组合物具有有用的体外、体内和有趣的免疫学和药理学活性；其制备方法；以及通过服用所述新型草药组合物治疗银屑病和相关免疫学和生物学疾病的方法。墨西哥刺五加（Argemone mexicana）叶和/或茎的提取物和馏分在体外、体内和有趣的免疫学和药理学方面表现出的有用活性。 Argemone mexicana 包括免疫抑制、淋巴细胞增殖抑制、细胞因子调节（如 IL-2 抑制、IFNgamma 抑制、IL-10 诱导）、角质细胞增殖抑制、角质溶解活性、内皮细胞增殖抑制、细胞粘附分子表达抑制（如 ICAM-1）、MEST 抑制、酶抑制（如 p60src 酪氨酸激酶），已知这些活性参与了抗银屑病活性。新型草药组合物可用于治疗各种疾病，如银屑病，包括斑块型银屑病、银屑病、脓疱型银屑病和指甲银屑病；皮炎和硬皮病；湿疹；炎症性疾病和其他自身免疫性疾病，如银屑病关节炎、类风湿性关节炎、克罗恩病、多发性硬化症、肠易激综合征、强直性脊柱炎、系统性红斑狼疮和 Sjogren 综合征；过敏症，如哮喘和慢性阻塞性肺病，并且安全、耐受性好、无毒、不良反应或副作用极小且可逆，最重要的是，在完成治疗方案后，疾病的复发或复发率极低。本发明还描述了孜然果实的水提取物、乙醇提取物或水乙醇提取物中存在磷酸二酯酶（III、IV 和 V）抑制作用和 5-脂氧合酶抑制作用。 孜然 植物。
• [EN] HERBAL COMPOSITION FOR TREATING VARIOUS DISORDERS INCLUDING PSORIASIS, A PROCESS FOR PREPARATION THEREOF AND METHOD FOR TREATMENT OF SUCH DISORDERS<br/>[FR] COMPOSITION A BASE DE PLANTES MEDICINALES PERMETTANT DE TRAITER PLUSIEURS TROUBLES PARMI LESQUELS LE PSORIASIS, PROCEDE DE PREPARATION DE CETTE COMPOSITION ET METHODE PERMETTANT DE TRAITER DE TELS TROUBLES
  申请人：——

  公开号：WO2003057133A9

  公开（公告）日：2004-08-12

  [EN] The invention provides a novel herbal composition containing the extracts of the leaves and/or stem of Argemone mexicana plant, optionally containing the extracts of the fruits of Cuminum cyminum, which exhibits useful in vitro, in vivo and interesting immunological and pharmacological activities; a process for preparation thereof; and a method of treatment of psoriasis and related immunological and biological disorders by administration of the said novel herbal composition. The useful in vitro, in vivo and interesting immunological and pharmacological activities exhibited by the extracts and fractions of the leaves and/or stem of Argemone mexicana plant include immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFNgamma inhibition, IL-10 induction, keratinocyte proliferation inhibition, keratolytic activity, endothelial cell proliferation inhibition, inhibition of cell adhesion molecule expression such as ICAM-1, NEST inhibition, and enzymes inhibition such as p60src Tyrosine kinase, which are known to be involved in anti-psoriatic activity. The novel herbal composition(s) is useful in the treatment of various disorders, such as psoriasis including plaque psoriasis, gutatte psoriasis, pustular psoriasis and psoriasis of the nails; dermatitis and scleroderma; eczema; inflammatory disorders and other autoimmune diseases like psoriatic arthritis, rheumatoid arthritis, Crohn's disease, multiple sclerosis, irritable bowel disease, ankylosing spondilitis, systemic lupus erythremetosus and Sjogren's syndrome; allergies like asthma and chronic obstructive pulmonary disease and is safe, well-tolerated, non-toxic, with minimal and reversible adverse reactions or side effects, and most importantly, with minimal relapse or recurrence of the disease following completion of a treatment regimen. The invention also describes the presence of phosphodiesterase (III, IV and V) inhibition and 5-Lipoxygenase inhibition in the aqueous, ethanolic or aqueous-ethanolic extracts of fruits of Cuminum cyminum plant.
  [FR] La présente invention concerne une nouvelle composition à base de plantes médicinales contenant des extraits de feuilles et/ou de pédoncules d'Argemone mexicana, éventuellement des extraits de fruits de Cuminum cyminum, laquelle composition présente des activités in vitro et in vivo utiles ainsi que des activités immunologiques et pharmacologiques intéressantes. L'invention concerne également un procédé permettant de préparer cette composition, et une méthode permettant de traiter le psoriasis ainsi que les troubles immunologiques et biologiques qui lui sont associés, par administration de la composition à base de plantes médicinales. Les activités in vivo et vitro et les activités immunologiques et pharmacologiques intéressantes présentées par ces extraits et fragments de feuilles et/ou de pédoncules d'Argemone mexicana comprennent l'immunosuppression, l'inhibition de la lymphoprolifération, la modulation de la cytokine, telle que l'inhibition de IL-2, l'inhibition de IFNgamma, l'induction de IL-10, l'inhibition de la prolifération des kératinocytes, l'activité kératolytique, l'inhibition de la prolifération des cellules endothéliales, l'inhibition de l'expression moléculaire par adhésion de cellules, telles que ICAM-1, l'inhibition de MEST, et l'inhibition d'enzymes telles que la p60src tyrosine kinase, enzymes connues pour être impliquées dans l'activité anti-psoriasique. La ou les nouvelles compositions à base de plantes médicinales sont utilises pour le traitement de divers troubles, tels que le psoriasis, y compris le psoriasis vulgaire, le psoriasis en gouttes, le psoriasis pustuleux et le psoriasis des ongles; la dermite et la sclérodermie; l'eczéma; des troubles inflammatoires et d'autres maladies auto-immunes, telles que l'arthrite psoriasique l'arthrite rhumatoïde, la maladie de Crohn, la sclérose en plaques, le syndrome du colon irritable, la spondylarthrite ankylosante, le lupus érythémateux disséminé et le syndrome de Sjogren; des allergies, telles que l'asthme et une maladie pulmonaire obstructive chronique. En outre, la ou les compositions sont fiables, bien tolérées, non toxiques; elles ont des effets indésirables ou des effets secondaires minimes et réversibles, et plus important encore, elles permettent une faible récidive ou récurrence de la maladie après régime de traitement. La présente invention concerne également l'inhibition des phosphodiestérases ((III, IV et V) et des 5-Lipoxygénases dans les extraits aqueux, éthanoliques ou aqueux-éthanoliques des fruits du Cuminum cyminum.