ε-Dimethylamino-caproamid | 4269-28-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ε-Dimethylamino-caproamid
• 英文别名: 6-(Dimethylamino)hexanamide
• CAS: 4269-28-7
• 化学式: C₈H₁₈N₂O
• 分子量: 158.244
• InChiKey: AQEZFKXZESMCDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-(dimethylamino)hexanoic acid 生成 ε-Dimethylamino-caproamid
  参考文献：
  名称：

  The IR spectra, the NIR spectra and the conformation of some basic amides

  摘要：

  DOI：

  10.1016/s0040-4020(01)93901-8

文献信息

• Acceptorless dehydrogenative synthesis of primary amides from alcohols and ammonia
  作者：Jie Luo、Quan-Quan Zhou、Michael Montag、Yehoshoa Ben-David、David Milstein

  DOI：10.1039/d1sc07102e

  日期：——

  existing catalytic systems instead generate other N-containing products, e.g., amines, imines and nitriles. Herein, we demonstrate an efficient and selective ruthenium-catalyzed synthesis of primary amides from alcohols and ammonia gas, accompanied by H2 liberation. Various aliphatic and aromatic primary amides were synthesized in high yields, with no observable N-containing byproducts. The selectivity

  通过无受体脱氢偶联直接从醇和氨合成广泛使用的伯酰胺是一种非常理想的方法，这代表了一种清洁、原子经济、可持续的过程。然而，这样的反应以前没有被报道过，并且现有的催化系统反而生成其他含氮产物，例如胺、亚胺和腈。在此，我们展示了一种高效、选择性的钌催化的由醇和氨气合成伯酰胺的方法，并伴随着 H 2 的释放。以高产率合成了各种脂肪族和芳香族伯酰胺，没有观察到含氮副产物。该系统对伯酰胺形成的选择性通过密度泛函理论（DFT）计算合理化，这表明半缩醛胺中间体脱氢成伯酰胺比脱水成亚胺更有利。
• 2,4,6-Trisubstituted Pyrimidines as Phosphotidylinositol (Pi) 3-Kinase Inhibitors and Their Use in the Treatment of Cancer
  申请人：Bailey Peter John

  公开号：US20080058332A1

  公开（公告）日：2008-03-06

  The invention concerns pyrimidine derivatives of Formula (I) wherein each of p, R 1 , R 2 , q, R 3 , r, R 4 , X 1 and Q 1 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the production of an anti-proliferative effect in a warm-blooded animal such as man.

  本发明涉及式(I)的嘧啶衍生物，其中p、R1、R2、q、R3、r、R4、X1和Q1中的每一个具有描述中定义的任何含义；制备它们的过程，含有它们的制药组合物以及它们在制造用于在诸如人类等恒温动物中产生抗增殖效应的药物的制剂中的使用。
• Amido functional amine catalysts for the production of polyurethanes
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP1038896A2

  公开（公告）日：2000-09-27

  The use of 3-[3-(dimethylamino)propyl]-propionamide (Formula I) and 3,3-[3-(dimethylamino)propyl]imino} bis-propanamide (Formula II) as catalysts in the production of polyurethanes.

  将 3-[3-(二甲基氨基)丙基]丙酰胺（式 I）和 3,3-[3-(二甲基氨基)丙基]亚氨基}双丙酰胺（式 II）用作生产聚氨酯的催化剂。
• Catalysts useful in polyurethane foam
  申请人：Chaffanjon Pierre

  公开号：US20050059749A1

  公开（公告）日：2005-03-17

  The invention provides amine catalyst composition useful in producing a polyurethane foam, which catalyst comprises a material described by the general structure: wherein R 1 and R 2 in each occurrence are independently selected from the group consisting of: methyl, ethyl, propyl, and butyl; m in each occurrence is any integer between 2 and about 10, including 2 and 10; and R 3 and R 4 are each independently selected from the group consisting of: hydrogen and C 1 to C 6 alkyl. flexible polyurethane foams produced using a catalyst according to the invention are low in odor, are not prone to discoloration, and have a low volatile organic chemical (VOC) content.

  本发明提供了用于生产聚氨酯泡沫的胺催化剂组合物，该催化剂由一般结构所述的材料组成： 其中 R 1 和 R 2 在每次出现时均独立地选自由甲基、乙基、丙基和丁基组成的组；m 在每次出现时均为 2 至约 10 之间的任意整数，包括 2 和 10；以及 R 3 和 R 4 各自独立地选自氢和 C 1 至 C 6 使用本发明的催化剂生产的软质聚氨酯泡沫气味小，不易变色，挥发性有机化学物质 (VOC) 含量低。
• Process for production of ethylene glycol and dimethyl carbonate
  申请人：TEXACO DEVELOPMENT CORPORATION

  公开号：EP0298167B1

  公开（公告）日：1992-09-16